Long‐term depression and long‐term potentiation in horizontal connections of the barrel cortex
Long‐term depression and long‐term potentiation in horizontal connections of the barrel cortex
复制标题
桶状皮层水平连接的长时程抑制和长时程增强
DOI：
10.1046/j.1460-9568.2002.02225.x
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发表时间：
2002
影响因子：
3.4
通讯作者：
Grzegorz Hess
中科院分区：
文献类型：
--
作者：
J. Urbán;M. Kossut;Grzegorz Hess
在成年小鼠的桶皮质中，对桶之间水平定向连接的突触可塑性进行了研究，切片横切成排的桶。在一桶柱的中间(在IV层或V层)诱发场电位，并在相邻的桶(在IV层和V层)记录场电位。在第IV层，先用低频刺激(2 HZ)刺激10 分钟，诱发26.5 ± 5%的长期抑郁(LTD)。30 分钟后，对先前被压抑的连接进行爆发性刺激，使长时程增强(LTP)增加28.8 ± 11.8%。当给予Theta-Burst刺激而不进行早期低频刺激时，不会诱发LTP。V层连接也有类似的结果(LTD：40.6 ± 12.5%；LTP：26.9 ± 12.5%)。在第IV层，应用N-甲基-D-天冬氨酸受体拮抗剂L-2-氨基-5-磷酸-丙交酯可阻断LTD和LTP的诱导。在第IV层，应用 -2-氨基-5-磷酸戊酸可阻断LTD和LTP的诱导。这些实验表明，在成年小鼠的颗粒层和颗粒下层中保留了突触可塑性的潜力。
Synaptic plasticity of horizontally orientated connections between barrels, in the barrel cortex of adult mice, was studied in slice preparations cut across rows of barrels. Field potentials were evoked in the middle of one barrel column (in layer IV or V) and recorded in the neighbouring barrel (in layer IV and V). In layer IV, long‐term depression (LTD) by 26.5 ± 5% was first induced by a low‐frequency stimulation (2 Hz) applied for 10 min. After 30 min, theta‐burst stimulation was delivered to previously depressed connections, resulting in long‐term potentiation (LTP) by 28.8 ± 11.8%. When theta‐burst stimulation was delivered without an earlier low‐frequency stimulation, no LTP was induced. Similar results were obtained in layer V connections (LTD: 40.6 ± 12.5%; LTP: 26.9 ± 12.5%). In layer IV, the application of 100 µm d,l‐2‐amino‐5‐phosphonovaleric acid (APV), an antagonist of NMDA receptors, blocked the induction of both LTD and LTP. These experiments show that a potential for synaptic plasticity is retained in granular and infragranular layers of adult mice.
影响因子：
2.5
作者：
KOSSUT, M;HAND, PJ;HAND, CL
通讯作者：
HAND, CL
成年大鼠桶状皮质中的 LTP。
影响因子：
1.7
作者：
Aroniadou-Anderjaska,V;Keller,A
通讯作者：
Keller,A