Free fatty acids profile among lean, overweight and obese non-alcoholic fatty liver disease patients: a case - control study.
Free fatty acids profile among lean, overweight and obese non-alcoholic fatty liver disease patients: a case - control study.
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瘦、超重和肥胖非酒精性脂肪肝患者的游离脂肪酸谱：病例对照研究
DOI：
10.1186/s12944-017-0551-1
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发表时间：
2017-09-04
影响因子：
4.5
通讯作者：
Niu Y
中科院分区：
文献类型：
--
作者：
Feng R;Luo C;Li C;Du S;Okekunle AP;Li Y;Chen Y;Zi T;Niu Y
非酒精性脂肪性肝病（NAFLD）与肥胖和糖尿病相关，可能会产生不同的游离脂肪酸（FFA）模式，但对这一现象的理解有限。为此，我们评估了健康受试者和按体重分层的NAFLD患者的FFA谱，以确定FFA对NAFLD早期诊断的价值。使用气相色谱-质谱法（GC-MS）测定健康和NAFLD（瘦、超重和肥胖）受试者的血清FFA谱，并使用单因素方差分析（ANOVA）评价FFA模式的差异，同时使用受试者工作特征（ROC）和逻辑回归模型来探索FFA对诊断NAFLD的意义。NAFLD患者血清FFA水平显著高于健康对照组（P < 0.05）。瘦型NAFLD患者（2093.33 ± 558.11 μg/ml）和超重型NAFLD患者（2420.81 ± 555.18 μg/ml）的总FFA谱无显著性差异，而肥胖型NAFLD患者（2739.01 ± 810.35 μg/ml）的总FFA谱显著高于高脂型（P < 0.05）。在四个FFA中，肉豆蔻酸（14：0）、棕榈油酸（16：1）、γ-亚麻酸（γ-18：3）和顺式-7，10，13，16，19-二十二碳五烯酸（22：5），由于其高Youden指数和AUC，在ROC分析中被选择，只有14：0; 5.58（1.37，22.76）和16：1; 4.36（1.34，14.13）具有统计学显著性比值比。我们的研究结果表明，14：0和16：1是有希望的NAFLD的早期诊断。本文的在线版本（doi：10.1186/s12944-017-0551-1）包含补充材料，可供授权用户使用。
Non-alcoholic fatty liver disease (NAFLD) given its association with obesity and diabetes may perhaps exert distinct free fatty acids (FFA) pattern, but the understanding of this phenomenon is limited. To this effect, we evaluated FFA profiles among healthy subjects and NAFLD patients stratified by body weight, to identify FFA valuable for early diagnosis of NAFLD. Serum FFA profiles of healthy and NAFLD (lean, overweight and obese) subjects was determined using gas chromatography–mass spectrometry (GC–MS) and distinctions in FFA patterns were evaluated using one-way ANOVA while Receiver operating characteristics (ROC) and logistic regression models were used to explore FFA significant for diagnosing NAFLD. NAFLD patients presented significantly higher (P < 0.05) serum FFA profiles compared to healthy controls (HC). While total FFA profiles were insignificantly different between lean (2093.33 ± 558.11 μg/ml) and overweight (2420.81 ± 555.18 μg/ml) NAFLD patients, obese NAFLD (2739.01 ± 810.35 μg/ml) presented most significantly elevated (P < 0.05) total FFA profiles compared with HC. Of the four FFA; myristic acid (14:0), palmitoleic acid (16:1), γ-linolenic acid (γ-18:3) and cis-7,10,13,16,19-docosapentaenoic acid (22:5), selected in ROC analysis given their high Youden’s index and AUC, only 14:0; 5.58(1.37, 22.76) and 16:1; 4.36(1.34, 14.13) had statistical significant odd ratios. Our findings suggest 14:0 and 16:1 are promising for early diagnosis of NAFLD. The online version of this article (doi:10.1186/s12944-017-0551-1) contains supplementary material, which is available to authorized users.
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影响因子：
5.9
作者：
Mustonen AM;Kärjä V;Kilpiö M;Tammi R;Tammi M;Rouvinen-Watt K;Halonen T;Nieminen P
通讯作者：
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DOI：
10.1016/j.numecd.2007.02.017
发表时间：
2008-07-01
影响因子：
3.9
作者：
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通讯作者：
Legrand, Philippe
影响因子：
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Poniachik, J