Severe acute malnutrition promotes bacterial binding over proinflammatory cytokine secretion by circulating innate immune cells.
Severe acute malnutrition promotes bacterial binding over proinflammatory cytokine secretion by circulating innate immune cells.
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DOI：
10.1126/sciadv.adh2284
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发表时间：
2023-11-03
期刊：
影响因子：
13.6
通讯作者：
Bourke, Claire D.
中科院分区：
文献类型：
--
作者：
Phiri, Tracy N.;Mutasa, Kuda;Rukobo, Sandra;Govha, Margaret;Mushayanembwa, Patience;Mwakamui, Simutanyi;Haider, Tafhima;Zyambo, Kanekwa;Dumbura, Cherlynn;Tome, Joice;Runodamoto, Thompson;Chidamba, Leah;Majo, Florence D.;Ngosa, Deophine;Chandwe, Kanta;Kapoma, Chanda;Mwapenya, Benjamin;Mufukari, Wadzanai;Sturgeon, Jonathan P.;Robertson, Ruairi C.;Smuk, Melanie;Ntozini, Robert;Nathoo, Kusum;Amadi, Beatrice;Kelly, Paul;Bwakura-Dangarembizi, Mutsa;Prendergast, Andrew J.;Bourke, Claire D.
患有严重急性营养不良(SAM)的儿童具有很高的感染性死亡率和发病率，这意味着他们的免疫防御系统存在缺陷。我们假设赞比亚和津巴布韦(n=141)因SAM住院的儿童(0至59个月)的循环先天免疫细胞与营养充足的健康对照组(n=92)相比具有不同的对细菌的反应能力。SAM患者中性粒细胞和单核细胞结合力高于对照组，单核细胞活化和促炎介质分泌对内毒素或热灭活鼠伤寒沙门氏菌的反应性低于对照组。在SAM患者中，浪费程度与细胞因子分泌呈负相关，HIV感染儿童单核细胞活化程度较低，最小的儿童在刺激下释放的髓过氧化物酶最少。住院患者的细菌结合能力和单核细胞激活与出院时持续SAM的几率较高相关，这是随后死亡的风险因素。因此，SAM改变了先天免疫细胞的功能，有利于细菌的遏制而不是促炎症的激活，这可能会导致出院后的健康缺陷。严重的急性营养不良会影响抗细菌的先天免疫细胞功能，并与持续性消耗有关。
Children with severe acute malnutrition (SAM) have high infectious mortality and morbidity, implicating defects in their immune defenses. We hypothesized that circulating innate immune cells from children (0 to 59 months) hospitalized with SAM in Zambia and Zimbabwe (n = 141) have distinct capacity to respond to bacteria relative to adequately nourished healthy controls (n = 92). SAM inpatients had higher neutrophil and monocyte Escherichia coli binding capacity but lower monocyte activation and proinflammatory mediator secretion in response to lipopolysaccharide or heat-killed Salmonella typhimurium than controls. Among SAM cases, wasting severity was negatively associated with cytokine secretion, children with HIV had lower monocyte activation, and the youngest children released the least myeloperoxidase upon stimulation. Inpatient bacterial binding capacity and monocyte activation were associated with higher odds of persistent SAM at discharge, a risk factor for subsequent mortality. Thus, SAM shifts innate immune cell function, favoring bacterial containment over proinflammatory activation, which may contribute to health deficits after discharge. Anti-bacterial innate immune cell function is shaped by severe acute malnutrition and associated with persistent wasting.
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影响因子：
28.3
作者：
Amadi B;Zyambo K;Chandwe K;Besa E;Mulenga C;Mwakamui S;Siyumbwa S;Croft S;Banda R;Chipunza M;Chifunda K;Kazhila L;VanBuskirk K;Kelly P
通讯作者：
Kelly P
使用基于豆类的饲料（Mimble）：一项试验试验，在严重急性营养不良的儿童中修饰肠道完整性和微生物组。
DOI：
10.1016/j.xcrm.2021.100280
发表时间：
2021-05-18
期刊：
Cell reports. Medicine
影响因子：
--
作者：
Calder N;Walsh K;Olupot-Olupot P;Ssenyondo T;Muhindo R;Mpoya A;Brignardello J;Wang X;McKay E;Morrison D;Holmes E;Frost G;Maitland K
通讯作者：
Maitland K
影响因子：
5.5
作者：
Grondman, Inge;Arts, Rob J. W.;Gresnigt, Mark S.
通讯作者：
Gresnigt, Mark S.
影响因子：
4.3
作者：
Chen H;Lau MC;Wong MT;Newell EW;Poidinger M;Chen J
通讯作者：
Chen J
影响因子：
16.8
作者：
Bourke CD;Berkley JA;Prendergast AJ
通讯作者：
Prendergast AJ