NETosis: a new factor in tumor progression and cancer-associated thrombosis.
NETosis: a new factor in tumor progression and cancer-associated thrombosis.
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DOI：
10.1055/s-0034-1370765
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发表时间：
2014-04
影响因子：
5.7
通讯作者：
Wagner DD
中科院分区：
文献类型：
--
作者：
Demers M;Wagner DD
中性粒细胞长期以来被认为是先天免疫细胞，它吞噬和杀死病原体并引起炎症反应，保护宿主免受感染。在过去的几十年里，中性粒细胞的新方面已经出现，揭示了它们不仅在炎症中，而且在包括血栓和癌症在内的许多病理条件下的重要性。2004年，中性粒细胞被强烈激活后，释放去致密染色质形成中性粒细胞胞外陷阱（NETs），这一发现开辟了新的研究途径。在这里，我们回顾了目前关于NETs在血栓形成中的知识，特别关注癌症相关血栓形成及其在癌症生长和转移中的潜在作用。我们讨论了NET特异性生物标志物的前景，如瓜氨酸组蛋白H3和NET抑制剂，作为预测和对抗癌症相关血栓形成的工具。我们认为，NETosis领域的快速发展可能为对抗癌症的血栓性后果提供新的靶点，甚至可能有助于控制疾病本身。
Neutrophils have long been known as innate immune cells that phagocytose and kill pathogens and mount inflammatory responses protecting the host from infection. In the last decades, new aspects of neutrophils have emerged unmasking their importance not only in inflammation, but also in many pathological conditions including thrombosis and cancer. The 2004 discovery that neutrophils, upon strong activation, release decondensed chromatin to form neutrophils extracellular traps (NETs), has unveiled new avenues of research. Here, we review current knowledge regarding NETs in thrombosis, with a special focus on cancer-associated thrombosis as well as their potential role in cancer growth and metastasis. We discuss the prospective use of NET-specific biomarkers, such as citrullinated histone H3 and NET inhibitors, as tools to anticipate and fight cancer-associated thrombosis. We propose that the rapid developments in the field of NETosis may provide new targets to combat the thrombotic consequences of cancer and perhaps even help to contain the disease itself.
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DOI：
10.1016/j.jvsv.2012.12.002
发表时间：
2013-10-01
期刊：
Journal of vascular surgery. Venous and lymphatic disorders
影响因子：
--
作者：
Diaz, J A;Fuchs, T A;Jackson, T O;Kremer Hovinga, J A;Lammle, B;Henke, P K;Myers, D D Jr;Wagner, D D;Wakefield, T W
通讯作者：
Wakefield, T W
影响因子：
3.8
作者：
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通讯作者：
Shen Z
影响因子：
7.3
作者：
Berger-Achituv S;Brinkmann V;Abed UA;Kühn LI;Ben-Ezra J;Elhasid R;Zychlinsky A
通讯作者：
Zychlinsky A
DOI：
10.1161/atvbaha.113.301627
发表时间：
2013-08
期刊：
Arteriosclerosis, thrombosis, and vascular biology
影响因子：
--
作者：
Borissoff JI;Joosen IA;Versteylen MO;Brill A;Fuchs TA;Savchenko AS;Gallant M;Martinod K;Ten Cate H;Hofstra L;Crijns HJ;Wagner DD;Kietselaer BLJH
通讯作者：
Kietselaer BLJH
影响因子：
7.5
作者：
Connolly GC;Khorana AA;Kuderer NM;Culakova E;Francis CW;Lyman GH
通讯作者：
Lyman GH