Cellular and systemic effects of anthrax lethal toxin and edema toxin.

Cellular and systemic effects of anthrax lethal toxin and edema toxin.
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DOI:
10.1016/j.mam.2009.07.003
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发表时间:
2009-12
影响因子:
10.6
通讯作者:
Leppla, Stephen H.
Leppla, Stephen H.
中科院分区:
医学1区
文献类型:
--
作者:
Moayeri, Mahtab;Leppla, Stephen H.

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炭疽致死毒素(LT)和水肿毒素(ET)是炭疽的主要毒力因子,可复制炭疽的致死性和症状。本文综述了炭疽毒素在动物模型中的作用以及LT在不同细胞中诱导的细胞毒性(坏死和凋亡)。在我们目前的知识背景下,毒素在体内的影响的早期历史性发现的简要重新审查。
Anthrax lethal toxin (LT) and edema toxin (ET) are the major virulence factors of anthrax and can replicate the lethality and symptoms associated with the disease. This review provides an overview of our current understanding of anthrax toxin effects in animal models and the cytotoxicity (necrosis and apoptosis) induced by LT in different cells. A brief reexamination of early historic findings on toxin in vivo effects in the context of our current knowledge is also presented.
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