Epigenetics of lung cancer.

Epigenetics of lung cancer.
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DOI:
10.1016/j.trsl.2014.03.001
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发表时间:
2015-01
期刊:
Translational research : the journal of laboratory and clinical medicine
影响因子:
--
通讯作者:
Kelsey KT
Kelsey KT
中科院分区:
其他
文献类型:
--
作者:
Langevin SM;Kratzke RA;Kelsey KT

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肺癌是美国癌症相关死亡率的主要原因。表观遗传学改变,包括DNA甲基化、组蛋白修饰和非编码RNA表达,在文献中已被广泛报道在肺癌的发生中起主要作用。这篇综述的目的是总结与肺癌相关的常见表观遗传学变化,以明确其病因,并概述这些变化的潜在翻译应用,包括早期检测,诊断,诊断和治疗的应用。
Lung cancer is the leading cause of cancer-related mortality in the United States. Epigenetic alterations, including DNA methylation, histone modifications, and non-coding RNA expression, have widely been reported in the literature to play a major role in the genesis of lung cancer. The goal of this review is to summarize the common epigenetic changes associated with lung cancer to give some clarity to its etiology, and provide an overview of the potential translational applications of these changes, including applications for early detection, diagnosis, prognostication, and therapeutics.
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