Survival after surgery for clinical stage I non-small-cell lung cancer with interstitial pneumonia.
Survival after surgery for clinical stage I non-small-cell lung cancer with interstitial pneumonia.
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临床 I 期非小细胞肺癌伴间质性肺炎手术后的生存率。
DOI：
10.1016/j.lungcan.2021.12.018
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发表时间：
2022
期刊：
影响因子：
5.3
通讯作者：
Suzuki K.
中科院分区：
文献类型：
--
作者：
Fukui M;Suzuki K;Ando K;Matsunaga T;Hattori A;Takamochi K;Nojiri S;Suzuki K.
目的 评估 I 期肺癌合并特发性间质性肺炎 (IIP) 患者术后的手术结果。 材料和方法 这项回顾性队列研究对 2009 年至 2018 年间接受肺切除术的 2131 例临床 I 期非小细胞肺癌 (NSCLC) 患者进行。根据计算机断层扫描 (CT) 结果，233 例患者患有 IIP。 180 名 IIP 患者和 1227 名无 IIP 患者进行了肺叶切除术。对手术结果、复发部位和死亡原因进行了调查。此外，我们测量了IIP患者肿瘤与肺门之间的距离，并评估了亚肺叶切除术的可行性。结果IIP患者的总生存期和癌症特异性生存期显着差于非IIP患者。伴或不伴IIP的临床IA/IB期肺癌患者的五年总生存率分别为58.1%/47.3%和88.8%/68.9%。此外，9.4% 的 IIP 患者和 0.9% 的非 IIP 患者在术后 2 年内死于呼吸系统相关原因。多变量分析显示，容量<80%（比值比：3.259）、CT发现的常见间质性肺炎模式（比值比：1.891）和淋巴结转移（比值比：3.304）是IIP患者总生存的预后因素。 22.3% 的 IIP 患者出现意外淋巴结转移。通过CT判断，接受肺叶切除术的IIP患者中有68%不适合进行亚肺叶切除。结论 IIP肺切除术后早期NSCLC患者总体生存率较差；这与癌症特异性和呼吸系统相关死亡的高发病率有关。亚肺叶切除并不总是可行，IIP患者的手术方式应根据每个病例的特点谨慎选择。无论肺切除范围如何，都应进行淋巴结清扫来评估转移情况。
ObjectivesTo evaluate the surgical outcomes after surgery in patients with stage I lung cancer and idiopathic interstitial pneumonia (IIP).Material and methodsThis retrospective cohort study was conducted in 2131 patients with clinical stage I non-small-cell lung cancer (NSCLC) who underwent pulmonary resection between 2009 and 2018. Based on computed tomography (CT) findings, 233 patients had IIP. Lobectomy was performed in 180 patients with IIP and 1227 patients without IIP. Surgical outcomes, recurrence sites, and cause of death were investigated. In addition, we measured the distance between the tumor and hilum in patients with IIP and assessed the feasibility of sublobar resection.ResultsThe overall survival and cancer-specific survival of patients with IIP were significantly poorer than those of non-IIP patients. The five-year overall survival rates of patients with clinical stage IA/IB lung cancer with and without IIP were 58.1%/47.3% and 88.8%/68.9%, respectively. Furthermore, 9.4% of patients with IIP and 0.9% of patients without IIP died from respiratory-related causes within 2 years after surgery. Multivariate analyses revealed that volume capacity <80% (odds ratio: 3.259), usual interstitial pneumonia pattern by CT finding (odds ratio: 1.891), and nodal metastasis (odds ratio: 3.304) were prognostic factors for overall survival in patients with IIP. Unexpected nodal metastases were observed in 22.3% of patients with IIP. By CT judgment, sublobar resection was not feasible in 68% of patients with IIP who underwent lobectomy.ConclusionsThe overall survival of patients with early NSCLC after pulmonary resection with IIP was poor; this is related to the high prevalence of cancer-specific and respiratory-related deaths. Sublobar resection is not always feasible, the procedure on patients with IIP should be selected carefully according to the characteristics of each case. Nodal dissection should be performed to evaluate for metastasis, regardless of the extent of lung resection.
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影响因子：
0.4
作者：
Betancourt-Cuellar, Sonia L.;Carter, Brett W.;Erasmus, Jeremy J.
通讯作者：
Erasmus, Jeremy J.
DOI：
10.6004/jnccn.2019.0059
发表时间：
2019-12-01
影响因子：
13.4
作者：
Ettinger, David S.;Wood, Douglas E.;Hughes, Miranda
通讯作者：
Hughes, Miranda
DOI：
10.1001/jama.2016.0518
发表时间：
2016-02-16
期刊：
JAMA
影响因子：
--
作者：
Putman RK;Hatabu H;Araki T;Gudmundsson G;Gao W;Nishino M;Okajima Y;Dupuis J;Latourelle JC;Cho MH;El-Chemaly S;Coxson HO;Celli BR;Fernandez IE;Zazueta OE;Ross JC;Harmouche R;Estépar RS;Diaz AA;Sigurdsson S;Gudmundsson EF;Eiríksdottír G;Aspelund T;Budoff MJ;Kinney GL;Hokanson JE;Williams MC;Murchison JT;MacNee W;Hoffmann U;O'Donnell CJ;Launer LJ;Harrris TB;Gudnason V;Silverman EK;O'Connor GT;Washko GR;Rosas IO;Hunninghake GM;Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) Investigators;COPDGene Investigators
通讯作者：
COPDGene Investigators
楔形切除与解剖切除：I 期和 II 期肺癌的手术切除范围。
DOI：
10.1200/edbk_179730
发表时间：
2017
期刊：
American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting
影响因子：
--
作者：
H. Asamura;K. Aokage;M. Yotsukura
通讯作者：
M. Yotsukura
DOI：
10.1007/s11748-004-0063-6
发表时间：
2004
期刊：
The Japanese journal of thoracic and cardiovascular surgery : official publication of the Japanese Association for Thoracic Surgery = Nihon Kyobu Geka Gakkai zasshi
影响因子：
--
作者：
T. Okamoto;M. Gotoh;D. Masuya;T. Nakashima;Dage Liu;K. Kameyama;S. Ishikawa;Yasumichi Yamamoto;Cheng‐long Huang;H. Yokomise
通讯作者：
H. Yokomise