Clinical analysis of interstitial pneumonia after surgery for lung cancer.
Clinical analysis of interstitial pneumonia after surgery for lung cancer.
复制标题
肺癌术后间质性肺炎的临床分析
DOI：
10.1007/s11748-004-0063-6
复制
发表时间：
2004
期刊：
影响因子：
--
通讯作者：
H. Yokomise
中科院分区：
文献类型：
--
作者：
T. Okamoto;M. Gotoh;D. Masuya;T. Nakashima;Dage Liu;K. Kameyama;S. Ishikawa;Yasumichi Yamamoto;Cheng‐long Huang;H. Yokomise
目的
肺癌患者术后发生或加重间质性肺炎（IP）常影响预后。我们分析了手术后发生IP的患者，以确定IP的治疗和预防。
方法
101例接受切除术的连续患者入组本研究。比较发生IP和未发生IP的患者的临床背景和围手术期后病程。
结果
如果IP发生或恶化，则采用类固醇脉冲（SP）治疗、免疫抑制剂（IS）治疗或一氧化氮（NO）吸入治疗。在101例患者中，20例在术前患有IP。在这20例患者中的4例（20%）中观察到术后恶化。所有患者均给予SP治疗。1例患者加用IS和NO治疗。4名患者中有3人死亡。81例患者未发生IP;其中3例（3.7%）在术后发生IP，并接受SP治疗。1例患者加用IS和NO治疗。三名患者中有两名死亡。在101例患者中的7例中观察到术后IP发展或恶化，其中5例死亡。在低分化鳞状细胞癌、肺功能检查限制性改变和一氧化碳弥散量低的患者中更常见。在接受肺叶切除术或肺切除术的患者中观察到术后发展或恶化。
结论
术后IP是一种严重的并发症。需要进一步的研究来确定明确的治疗方案。对于存在上述危险因素的患者，必须考虑有限的手术。
OBJECTIVE
The postoperative development or exacerbation of interstitial pneumonia (IP) in lung cancer patients often affects prognoses. We analyzed the patients who suffered from IP after surgery, to determine treatment and prevention of IP.
METHODS
One hundred and one consecutive patients who underwent resection were enrolled in the study. Clinical background and post-, perioperative course were compared between patients who developed IP and those who did not.
RESULTS
If IP developed or was exacerbated, steroid pulse (SP) therapy, immunosuppressant (IS) therapy or nitric oxide (NO) inhalation therapy was employed. Of 101 patients, 20 had suffered from IP before surgery. In four of these 20 (20%), postoperative exacerbation was observed. SP therapy was given to all patients. To one patient, IS and NO therapy were added. Three of the four patients died. 81 patients did not have IP; three of them (3.7%) developed IP after the operation and were treated with SP therapy. To one patient, IS and NO therapy were added. Two of the three patients died. IP development or exacerbation after surgery was observed in seven of 101 patients, and five of them died. It was significantly more frequent in patients with poorly differentiated squamous cell carcinoma, restrictive change in pulmonary function tests, and a low percentage diffusion capacity for carbon monoxide. Postoperative development or exacerbation was observed in patients who had undergone lobectomy or pneumonectomy.
CONCLUSIONS
Postoperative IP is a serious complication. Further studies are needed to determine definitive therapeutic options. For the patients with the aforementioned risk factors, limited surgery must be considered.
特发性肺纤维化结构与功能的相关性。
DOI：
10.1164/ajrccm/151.4.1180
发表时间：
1995
期刊：
American journal of respiratory and critical care medicine.
影响因子：
--
作者：
Cherniack,RM;Colby,TV;Flint,A;Thurlbeck,WM;WaldronJr,JA;Ackerson,L;Schwarz,MI;KingJr,TE
通讯作者：
KingJr,TE