Oral administration of Bifidobacterium bifidum G9-1 suppresses total and antigen specific immunoglobulin E production in mice.
Oral administration of Bifidobacterium bifidum G9-1 suppresses total and antigen specific immunoglobulin E production in mice.
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口服两歧双歧杆菌 G9-1 可抑制小鼠体内总免疫球蛋白 E 和抗原特异性免疫球蛋白 E 的产生。
DOI：
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发表时间：
2005
影响因子：
2
通讯作者：
H. Yamamura
中科院分区：
文献类型：
--
作者：
H. Ohno;Satoru Tsunemine;Y. Isa;M. Shimakawa;H. Yamamura
最近的研究表明，口腔细菌治疗与益生菌可能是有用的过敏性疾病的管理。研究了口服两歧双歧杆菌G9-1（Bifidobacterium bifidum G9-1，BBG 9 -1）对BALB/c小鼠免疫球蛋白（IG）E产生的影响。从卵清蛋白（OVA）免疫前1周起，将活BBG 9 -1口服给予小鼠2周。BBG 9 -1治疗显著降低血清总IgE水平。另外，BBG 9 -1显著且大幅降低了血清中OVA特异性IgE的水平，而没有降低特异性IgG 1和增加特异性IgG 2a。我们还研究了辅助性T细胞类型（Th）1和Th 2细胞因子的生产从卵蛋白免疫的脾细胞再刺激与卵蛋白在体外。从给予BBG 9 -1的小鼠的脾细胞产生的干扰素（IFN）-γ、白细胞介素（IL）-4和IL-5弱于对照小鼠。我们的结论是，口服BBG 9 -1选择性地和有力地抑制总的和抗原特异性IgE在小鼠中的生产。提示BBG 9 -1可用于IgE依赖性变态反应性疾病的预防性治疗。
Recent studies have suggested that oral bacteriotherapy with probiotics might be useful in the management of allergic diseases. We investigated the effect of oral administration of Bifidobacterium bifidum G9-1 (BBG9-1) on immunoglobulin (Ig) E production in BALB/c mice. Live BBG9-1 was orally administered to mice for 2 weeks from 1 week before ovalbumin (OVA)-immunization. The treatment of BBG9-1 significantly reduced serum total IgE level. In addition, BBG9-1 significantly and largely reduced the serum level of OVA-specific IgE without lowering of the specific IgG1 and increasing of the specific IgG2a. We also examined T helper type (Th) 1 and Th2 cytokine production from OVA-immunized splenocytes by restimulation with OVA in vitro. Productions of interferon (IFN)-gamma, interleukin (IL)-4 and IL-5 from the splenocytes of mice given BBG9-1 were weaker than those of control mice. We conclude that oral administration of BBG9-1 selectively and powerfully suppresses total and antigen specific IgE production in mice. It is suggested that BBG9-1 is useful for the prophylactic treatment in IgE-dependent allergic diseases.
影响因子：
56.9
作者：
CHEN, YH;KUCHROO, VK;WEINER, HL
通讯作者：
WEINER, HL
DOI：
10.1073/pnas.89.1.421
发表时间：
1992-01-01
影响因子：
11.1
作者：
MILLER, A;LIDER, O;WEINER, HL
通讯作者：
WEINER, HL
DOI：
10.1073/pnas.93.1.388
发表时间：
1996-01-09
影响因子：
11.1
作者：
Chen, YH;Inobe, J;Weiner, HL
通讯作者：
Weiner, HL