The global survival rate of graft and patient in kidney transplantation of children: a systematic review and meta-analysis.
The global survival rate of graft and patient in kidney transplantation of children: a systematic review and meta-analysis.
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DOI：
10.1186/s12887-022-03545-2
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发表时间：
2022-08-24
期刊：
影响因子：
2.4
通讯作者：
中科院分区：
文献类型：
--
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本研究是对已发表的关于儿童肾移植中移植物和患者总体存活率的研究进行的系统综述和荟萃分析。使用系统检索策略，在以下数据库中选择截至2020年12月30日发表的研究肾移植存活率的研究：Medline、Embase、Scopus、ProQuest、ISI Web of Science和科克伦。将提取的数据输入Excel软件和STATA 16.0。检索识别出6007篇研究参考文献。从总数中，我们排除了1348篇重复文献，3688篇被认为不相关的参考文献标题和摘要，以及846篇非原创文献（即，信、评论、综述）或不符合入选标准。因此，本荟萃分析纳入了涉及12，330名参与者的89项研究。移植肾1、3、5、7、10年生存率分别为92、83、74.40、67.10、63.50%。患者的1、3、5、7和10年生存率分别为99.60%、97.30%、95.20%、74.60%和97.90%。研究结果表明，肾移植儿童的移植物和患者存活率存在差异。虽然种族血统、与已故供体肾脏的不相容性以及肾脏疾病类型的差异是不可避免的，但在少数群体中特别需要采取干预措施，以改善预防性和活体供体移植。此外，还需要进行更多的研究，以确定和解决医疗和社会文化障碍对这些群体的优惠待遇所起的作用。在线版本包含补充材料，可通过10.1186/s12887-022-03545-2获得。
This study is a systematic review and meta-analysis on published studies about the Global Survival Rate of Graft and Patients in the Kidney Transplantation of children. Studies that investigated the survival rate of kidney transplants published until the 30th of December 2020 were selected using a systematic search strategy in the following databases: Medline, Embase, Scopus, ProQuest, ISI Web of Science, and Cochrane. The extracted data were entered into the Excel software and STATA 16.0. The search identified 6007 study references. From the total, we excluded 1348 duplicates, 3688 reference titles and abstracts that were deemed irrelevant, and 846 references that were not original articles (i.e., letter, commentary, review) or did not meet the inclusion criteria. As such, 89 studies involving 12,330 participants were included in this meta-analysis. In this study 1, 3, 5, 7 and 10-year survival rates of graft were estimated to be 92, 83, 74.40, 67.10, and 63.50%, respectively. Also, 1, 3, 5, 7 and 10-year survival rates of patients were estimated to be 99.60, 97.30, 95.20, 74.60, and 97.90%, respectively. The findings suggest differences in graft and patient survival among children with kidney transplants. Although differences in ethnic origin, incompatibility with deceased donor kidneys, and types of kidney disease are unavoidable, interventions to improve preventive and living-donor transplantation are particularly needed in minority groups. In addition, more research is needed to establish and address the contribution of medical and sociocultural barriers to preferential treatment of these groups. The online version contains supplementary material available at 10.1186/s12887-022-03545-2.
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影响因子：
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作者：
Assadi, Farahnak
通讯作者：
Assadi, Farahnak
影响因子：
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作者：
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