Association between decreasing trend in the mortality of adult T-cell leukemia/lymphoma and allogeneic hematopoietic stem cell transplants in Japan: analysis of Japanese vital statistics and Japan Society for Hematopoietic Cell Transplantation (JSHCT).
Association between decreasing trend in the mortality of adult T-cell leukemia/lymphoma and allogeneic hematopoietic stem cell transplants in Japan: analysis of Japanese vital statistics and Japan Society for Hematopoietic Cell Transplantation (JSHCT).
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DOI：
10.1038/bcj.2013.57
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发表时间：
2013-11-15
影响因子：
12.8
通讯作者：
Matsuo, K.
中科院分区：
文献类型：
--
作者：
Chihara, D.;Ito, H.;Matsuda, T.;Katanoda, K.;Shibata, A.;Taniguchi, S.;Utsunomiya, A.;Sobue, T.;Matsuo, K.
成人 T 细胞白血病/淋巴瘤 (ATLL) 是一种外周 T 细胞肿瘤，预后极差。然而，一些研究表明治疗取得了进展。为了评估整个患者群体中 ATLL 治疗进展的效果，我们使用了生命统计数据并估计了 1995 年至 2009 年的年龄调整死亡率和死亡率趋势。由于异基因造血干细胞移植（allo-HSCT）已作为研究期间具有治愈潜力的方式被引入，我们还评估了每年异基因造血干细胞移植数量与 ATLL 死亡率趋势之间的关系。流行地区（九州）和非流行地区（其他）分别进行评估。通过连接点回归分析评估死亡率趋势的显着性。研究期间，日本共有 14 932 名患者死于 ATLL，两个地区的死亡率均显着下降（年度百分比变化（95% 置信区间 (CI)）：九州，-3.1%（-4.3，-1.9）；其他地区，-3.4%（-5.3，-1.5））。这种死亡率的下降趋势似乎与allo-HSCT数量的增加有关（九州，R平方=0.70，P=0.003；其他，R平方=0.55，P=0.058）。这项研究表明，日本 ATLL 的死亡率目前正在显着下降，这种下降趋势可能与异基因造血干细胞移植有关。
Adult T-cell leukemia/lymphoma (ATLL) is a peripheral T-cell neoplasm with a very poor outcome. However, several studies have shown a progress in the treatment. To evaluate the effect of the progress in the treatment of ATLL in a whole patient population, we used vital statistics data and estimated age-adjusted mortality and trends in the mortality from 1995 to 2009. Since allogeneic hematopoietic stem-cell transplantation (allo-HSCT) has been introduced as a modality with curative potential during study period, we also evaluated the association of the annual number of allo-HSCT and the trend of the mortality of ATLL. Endemic (Kyushu) and non-endemic areas (others) were evaluated separately. Significance in the trend of mortality was evaluated by joinpoint regression analysis. During the study period, a total of 14 932 patients died of ATLL in Japan, and mortality decreased significantly in both areas (annual percent change (95% confidence interval (CI)): Kyushu, −3.1% (−4.3, −1.9); others, −3.4% (−5.3, −1.5)). This decreasing trend in mortality seems to be associated with an increase in the number of allo-HSCTs (Kyushu, R-squared=0.70, P=0.003; and others, R-squared=0.55, P=0.058). This study reveals that the mortality of ATLL is now significantly decreasing in Japan and this decreasing trend might be associated with allo-HSCT.
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影响因子：
5.7
作者：
Chihara, Dai;Ito, Hidemi;Matsuo, Keitaro
通讯作者：
Matsuo, Keitaro
影响因子：
4.3
作者：
Kato, Koji;Kanda, Yoshinobu;Harada, Mine
通讯作者：
Harada, Mine
影响因子：
45.3
作者：
Tsukasaki, Kunihiro;Hermine, Olivier;Watanabe, Toshiki
通讯作者：
Watanabe, Toshiki
影响因子：
45.3
作者：
Tsukasaki, Kunihiro;Utsunomiya, Atae;Tomonaga, Masao
通讯作者：
Tomonaga, Masao
影响因子：
20.3
作者：
Okamura, J;Utsunomiya, A;Saburi, Y
通讯作者：
Saburi, Y