Measurement of pulmonary status and surfactant protein levels during dexamethasone treatment of neonatal respiratory distress syndrome.
Measurement of pulmonary status and surfactant protein levels during dexamethasone treatment of neonatal respiratory distress syndrome.
复制标题
地塞米松治疗新生儿呼吸窘迫综合征期间肺部状态和表面活性剂蛋白水平的测量。
作者：
J. Y. Wang;T. Yeh;Y. Lin;K. Miyamura;U. Holmskov;K. Reid
背景：对于患有呼吸窘迫综合征（RDS）的婴儿，产后早期使用地塞米松已被证明可以有效改善肺部状况并允许早期脱离机械通气。然而，解释地塞米松对通气依赖型早产儿有益作用的机制仍不清楚。方法：进行了一项双盲、安慰剂对照研究，以确定地塞米松治疗对 RDS 早产儿肺通气的变化，并评估地塞米松对 34 名 RDS 早产儿和 29 名对照受试者气管液中表面活性剂相关蛋白 A (SP-A) 和 D (SP-D) 水平的影响。结果：地塞米松治疗降低了吸入氧浓度分数 (FIO2)、动脉二氧化碳张力 (PCO2)、平均气道压力 (MAP)，并促进了机械通气的成功脱机。与对照组相比，地塞米松治疗组气管抽吸物中的 SP-A 浓度在第 7 天和第 14 天增加，SP-D 浓度在第 3 天至 14 天期间增加。然而，地塞米松治疗后第 3 天至第 14 天期间，气管吸出物样本中的白蛋白水平下降。PCO2 值与 SP-A 浓度之间存在负相关。结论：这些结果表明，早期使用地塞米松可以改善 RDS 早产儿的肺部状况，并增加气管液中 SP-A 和 SP-D 的水平。
BACKGROUND: Early postnatal use of dexamethasone in infants with respiratory distress syndrome (RDS) has been shown effectively to improve pulmonary status and to allow early weaning off mechanical ventilation. However, the mechanisms to explain the beneficial effects of dexamethasone in ventilatory dependent preterm infants remain unclear. METHODS: A double blind, placebo controlled study was performed to determine the change in pulmonary ventilation of premature infants with RDS as a result of dexamethasone treatment, and to evaluate the effect of dexamethasone on the levels of surfactant-associated proteins A (SP-A) and D (SP-D) in the tracheal fluid from 34 premature infants with RDS and 29 control subjects. RESULTS: Dexamethasone treatment decreased fractional inspired oxygen concentration (FIO2), arterial carbon dioxide tension (PCO2), mean airway pressure (MAP), and facilitated successful weaning from mechanical ventilation. SP-A concentrations in the tracheal aspirates were increased at days 7 and 14, and SP-D concentrations were increased during the period from days 3 to 14 in the dexamethasone treated group compared with the control group. However, albumin levels in the tracheal aspirate samples were decreased after dexamethasone treatment over the period from days 3 to 14. There was an inverse correlation between PCO2 values and SP-A concentrations. CONCLUSIONS: These results suggest that early use of dexamethasone can improve pulmonary status and also increase SP-A and SP-D levels in the tracheal fluid in premature infants with RDS.
糖皮质激素对体外和体内表面活性蛋白 D 表达的调节。
DOI：
10.1165/ajrcmb.10.1.8292379
发表时间：
1994
影响因子：
6.4
作者：
Deterding,RR;Shimizu,H;Fisher,JH;Shannon,JM
通讯作者：
Shannon,JM
死于呼吸窘迫综合征的婴儿肺部中 35kDa 和低分子量表面活性剂相关蛋白的表达。
DOI：
--
发表时间：
1989
期刊：
The American journal of pathology
影响因子：
--
作者：
deMello,DE;Phelps,DS;Patel,G;Floros,J;Lagunoff,D
通讯作者：
Lagunoff,D
表面活性剂治疗后呼吸窘迫综合征婴儿气管抽吸物中的表面活性剂相关蛋白。
DOI：
10.1164/ajrccm/137.4.943
发表时间：
1988
期刊：
The American review of respiratory disease
影响因子：
--
作者：
Chida,S;Phelps,DS;Cordle,C;Soll,R;Floros,J;Taeusch,HW
通讯作者：
Taeusch,HW