Mesothelin is a specific biomarker of invasive cancer in the Barrett-associated adenocarcinoma progression model: translational implications for diagnosis and therapy.
Mesothelin is a specific biomarker of invasive cancer in the Barrett-associated adenocarcinoma progression model: translational implications for diagnosis and therapy.
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间皮素是与巴雷特相关的腺癌进展模型中侵入性癌症的特定生物标志物：对诊断和治疗的转化意义。
DOI：
10.1016/j.nano.2008.06.006
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发表时间：
2008-12
影响因子：
5.4
通讯作者：
Maitra, Anirban
中科院分区：
文献类型：
--
作者：
Alvarez, Hector;Rojas, Pamela Leal;Yong, Ken-Tye;Ding, Hong;Xu, Gaixia;Prasad, Paras N.;Wang, Jean;Canto, Marcia;Eshleman, James R.;Montgomery, Elizabeth A.;Maitra, Anirban
关键词：
Esophageal adenocarcinoma arises in the backdrop of Barrett metaplasia-dysplasia sequence, with the vast majority of patients presenting with late stage malignancy. Mesothelin, a GPI-anchored protein, is aberrantly overexpressed on the surface of many solid cancers. Mesothelin expression was assessed in esophageal tissue microarrays (TMAs) encompassing the entire histologic spectrum of Barrett-associated dysplasia and adenocarcinoma. Mesothelin expression was observed in 24/84 (29%) of invasive adenocarcinomas, and in 5/34 (15%) lymph node metastases. In contrast, normal squamous and cardia mucosa, as well as non-invasive Barrett lesions, failed to label with mesothelin. Mesothelin was expressed in the esophageal adenocarcinoma cell line JHU-EsoAd1, but not in primary human esophageal epithelial cells. Anti-mesothelin antibody conjugated CdSe/CDS/ZnS quantum rods (QRs) were synthesized as described (Young et al, NanoLetters, 2007), and confocal bio-imaging confirmed robust binding to JHU-EsoAd1 cells. Anti-mesothelin antibody conjugated nanoparticles can be useful for the diagnosis and therapy of mesothelin-overexpressing esophageal adenocarcinomas.
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影响因子：
3.9
作者：
Hassan, R;Viner, JL;Pastan, I
通讯作者：
Pastan, I
影响因子：
5.1
作者：
Chang, C-L;Wu, T-C;Hung, C-F
通讯作者：
Hung, C-F
影响因子：
9.6
作者：
Creaney, Jenette;van Bruggen, Ivonne;Robinson, Bruce W. S.
通讯作者：
Robinson, Bruce W. S.
影响因子：
5.5
作者：
Hung, Chien-Fu;Calizo, Roanne;Wu, T-C
通讯作者：
Wu, T-C
影响因子：
--
作者：
Corso, Christopher D.;Stubbs, Desmond D.;Hunt, William D.
通讯作者：
Hunt, William D.