Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians.
Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians.
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DOI:
10.1136/bmj.k601
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发表时间:
2018-07-12
期刊:
影响因子:
--
通讯作者:
Davey Smith G
中科院分区:
文献类型:
--
作者:
Davies NM;Holmes MV;Davey Smith G
Mendelian randomisation uses genetic variation as a natural experiment to investigate the causal relations between potentially modifiable risk factors and health outcomes in observational data. As with all epidemiological approaches, findings from Mendelian randomisation studies depend on specific assumptions. We provide explanations of the information typically reported in Mendelian randomisation studies that can be used to assess the plausibility of these assumptions and guidance on how to interpret findings from Mendelian randomisation studies in the context of other sources of evidence
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