Mechanisms of neuroinflammation in hydrocephalus after intraventricular hemorrhage: a review.
Mechanisms of neuroinflammation in hydrocephalus after intraventricular hemorrhage: a review.
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DOI：
10.1186/s12987-022-00324-0
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发表时间：
2022-04-01
影响因子：
7.3
通讯作者：
Xi G
中科院分区：
文献类型：
--
作者：
Holste KG;Xia F;Ye F;Keep RF;Xi G
脑室内出血（IVH）是新生儿和成人发病率和死亡率的重要原因。IVH不仅通过质量效应和颅内压升高对周围结构造成直接损害;随后的炎症导致额外的脑损伤和水肿。在那些经历严重IVH的新生儿中，25-30%将继续发展出血后脑积水（PHH）。PHH使新生儿和成人处于白色物质损伤、癫痫发作和死亡的风险中。不幸的是，PHH的分子决定因素还没有得到很好的理解。在过去的十年中，重点放在IVH和PHH的神经炎症上。关于炎症诱导的纤维化和脑脊液高分泌对IVH的反应的更多信息已经被发现。本文综述了血栓源性神经炎症因子（包括血红蛋白/铁、过氧化物氧还蛋白-2和凝血酶）以及巨噬细胞/小胶质细胞、细胞因子和补体在PHH发生发展中的作用。了解IVH后神经炎症的机制可能会突出PHH潜在的新治疗靶点。
Intraventricular hemorrhage (IVH) is a significant cause of morbidity and mortality in both neonatal and adult populations. IVH not only causes immediate damage to surrounding structures by way of mass effect and elevated intracranial pressure; the subsequent inflammation causes additional brain injury and edema. Of those neonates who experience severe IVH, 25–30% will go on to develop post-hemorrhagic hydrocephalus (PHH). PHH places neonates and adults at risk for white matter injury, seizures, and death. Unfortunately, the molecular determinants of PHH are not well understood. Within the past decade an emphasis has been placed on neuroinflammation in IVH and PHH. More information has come to light regarding inflammation-induced fibrosis and cerebrospinal fluid hypersecretion in response to IVH. The aim of this review is to discuss the role of neuroinflammation involving clot-derived neuroinflammatory factors including hemoglobin/iron, peroxiredoxin-2 and thrombin, as well as macrophages/microglia, cytokines and complement in the development of PHH. Understanding the mechanisms of neuroinflammation after IVH may highlight potential novel therapeutic targets for PHH.
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DOI：
10.1038/s41582-020-00447-8
发表时间：
2021-04
期刊：
Nature reviews. Neurology
影响因子：
--
作者：
Ballabh P;de Vries LS
通讯作者：
de Vries LS
辛伐他汀部分通过上调 CD36 促进血肿吸收并减少脑室内出血后的脑积水
影响因子：
6.9
作者：
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通讯作者：
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DOI：
10.3109/08977194.2011.595714
发表时间：
2011-10
期刊：
Growth factors (Chur, Switzerland)
影响因子：
--
作者：
Biernacka A;Dobaczewski M;Frangogiannis NG
通讯作者：
Frangogiannis NG
影响因子：
3.6
作者：
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影响因子：
1.9
作者：
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