Anthracycline-induced cardiotoxicity: From pathobiology to identification of molecular targets for nuclear imaging.
Anthracycline-induced cardiotoxicity: From pathobiology to identification of molecular targets for nuclear imaging.
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DOI：
10.3389/fcvm.2022.919719
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发表时间：
2022
影响因子：
3.6
通讯作者：
Packard, Rene R. Sevag
中科院分区：
文献类型：
--
作者：
Jong, Jeremy;Pinney, James R.;Packard, Rene R. Sevag
蒽环类药物是儿童和成人癌症中广泛使用的一类化疗药物，然而，它们的使用受到心脏毒性副作用和随之而来的并发症（主要是心力衰竭）的发展的阻碍。临床上用于筛选心脏毒性的成像方式主要是超声心动图和偶尔的心脏磁共振成像。然而，舒张和整体或节段性收缩功能的评估可能对检测亚临床或早期心脏毒性不敏感。多项研究已经仔细研究了分子核成像策略，以提高对蒽环类药物引起的心脏毒性的检测。蒽环类药物可以激活心肌细胞中各种形式的细胞死亡。与蒽环类药物使用相关的损伤机制包括细胞凋亡、坏死、自噬、铁亡、焦亡、活性氧、线粒体功能障碍、心脏纤维化、交感神经驱动和心肌血流紊乱；其中一些已经被核探测器盯上了。本文回顾了蒽环类药物引起的心脏损伤的病理生物学，详细介绍了迄今为止支持分子核成像策略的证据，探讨了尚未针对的疾病机制，并提出了结合分子成像来改善患者管理的临床策略。
Anthracyclines are a widely used class of chemotherapy in pediatric and adult cancers, however, their use is hampered by the development of cardiotoxic side-effects and ensuing complications, primarily heart failure. Clinically used imaging modalities to screen for cardiotoxicity are mostly echocardiography and occasionally cardiac magnetic resonance imaging. However, the assessment of diastolic and global or segmental systolic function may not be sensitive to detect subclinical or early stages of cardiotoxicity. Multiple studies have scrutinized molecular nuclear imaging strategies to improve the detection of anthracycline-induced cardiotoxicity. Anthracyclines can activate all forms of cell death in cardiomyocytes. Injury mechanisms associated with anthracycline usage include apoptosis, necrosis, autophagy, ferroptosis, pyroptosis, reactive oxygen species, mitochondrial dysfunction, as well as cardiac fibrosis and perturbation in sympathetic drive and myocardial blood flow; some of which have been targeted using nuclear probes. This review retraces the pathobiology of anthracycline-induced cardiac injury, details the evidence to date supporting a molecular nuclear imaging strategy, explores disease mechanisms which have not yet been targeted, and proposes a clinical strategy incorporating molecular imaging to improve patient management.
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影响因子：
2.1
作者：
Nehmeh SA;Fox JJ;Schwartz J;Ballangrud ÅM;Schöder H;Zhao Y;Strauss HW;Yu A;Gupta D;Powell SN;Ho AY
通讯作者：
Ho AY
[(123)I]MIBG 是比 [(18)F]FDG 更好的蒽环类心脏毒性早期标志物：临床前 SPECT/CT 和同步 PET/MR 研究。
影响因子：
3.2
作者：
Oudot A;Courteau A;Guillemin M;Vrigneaud JM;Walker PM;Brunotte F;Cochet A;Collin B
通讯作者：
Collin B
影响因子：
2.4
作者：
Bauckneht, Matteo;Pastorino, Fabio;Marini, Cecilia
通讯作者：
Marini, Cecilia
影响因子：
37.8
作者：
ARMBRECHT, JJ;BUXTON, DB;SCHELBERT, HR
通讯作者：
SCHELBERT, HR
DOI：
10.1161/circheartfailure.115.002661
发表时间：
2016-01
期刊：
Circulation. Heart failure
影响因子：
--
作者：
Bloom MW;Hamo CE;Cardinale D;Ky B;Nohria A;Baer L;Skopicki H;Lenihan DJ;Gheorghiade M;Lyon AR;Butler J
通讯作者：
Butler J