[(123)I]MIBG is a better early marker of anthracycline cardiotoxicity than [(18)F]FDG: a preclinical SPECT/CT and simultaneous PET/MR study.
[(123)I]MIBG is a better early marker of anthracycline cardiotoxicity than [(18)F]FDG: a preclinical SPECT/CT and simultaneous PET/MR study.
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[(123)I]MIBG 是比 [(18)F]FDG 更好的蒽环类心脏毒性早期标志物：临床前 SPECT/CT 和同步 PET/MR 研究。
DOI：
10.1186/s13550-021-00835-1
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发表时间：
2021-09-20
期刊：
影响因子：
3.2
通讯作者：
Collin B
中科院分区：
文献类型：
--
作者：
Oudot A;Courteau A;Guillemin M;Vrigneaud JM;Walker PM;Brunotte F;Cochet A;Collin B
在蒽环类药物治疗癌症的过程中，除了心功能障碍外，还缺乏心脏毒性的生物标志物。本研究的目的是比较[18 F]FDG和[123 I]MIBG（间碘苄胍）在多柔比星诱导的心脏毒性大鼠模型的纵向研究。雄性Wistar Han大鼠以10天间隔静脉内施用盐水或阿霉素（5 mg/kg）3次。在第一次多柔比星/生理盐水注射前24 h间隔和6周内每2周一次进行[123 I]MIBG SPECT/CT（单光子发射计算机断层扫描-计算机断层扫描）和同步[18 F]FDG PET（正电子发射断层扫描）/7 T心脏MR（磁共振）成像采集。在6周时，收集心脏组织用于组织形态计量学测量。在第4周，左心室（LV）舒张末期容积显着减少阿霉素组。第6周时，左心室舒张末期容积维持降低，左心室收缩末期容积增加，导致左心室射血分数显著降低（47 ± 6% vs. 70 ± 3%）。在第4周和第6周，心肌[18F]FDG摄取与对照组相比降低（第6周分别为4.2 ± 0.5%ID/g和9.2 ± 0.8%ID/g），但在第2周没有降低。此外，[18F]FDG心脏摄取与心功能损害相关。相比之下，从第2周开始，在阿霉素组中检测到心肌[123 I]MIBG心脏与纵隔比率显著降低，并在第4周和第6周维持，第6周降低45.6%。这项纵向研究精确地表明，多柔比星治疗后，心脏[123 I]MIBG摄取早在2周就显著降低，随后在4周时LV舒张末期容积和[18 F]FDG摄取降低，最后在6周时LV收缩末期容积增加和LV射血分数降低。因此，心脏神经支配成像应被视为蒽环类药物心脏毒性的早期关键特征。在线版本包含补充材料，可通过10.1186/s13550-021-00835-1获得。
During anthracycline treatment of cancer, there is a lack for biomarkers of cardiotoxicity besides the cardiac dysfunction. The objective of the present study was to compare [18F]FDG and [123I]MIBG (metaiodobenzylguanidine) in a longitudinal study in a doxorubicin-induced cardiotoxicity rat model. Male Wistar Han rats were intravenously administered 3 times at 10 days’ interval with saline or doxorubicin (5 mg/kg). [123I]MIBG SPECT/CT (single photon emission computed tomography-computed tomography) and simultaneous [18F]FDG PET (positron emission tomography)/7 Tesla cardiac MR (magnetic resonance) imaging acquisitions were performed at 24 h interval before first doxorubicin / saline injection and every 2 weeks during 6 weeks. At 6 weeks, the heart tissue was collected for histomorphometry measurements. At week 4, left ventricle (LV) end-diastolic volume was significantly reduced in the doxorubicin group. At week 6, the decreased LV end-diastolic volume was maintained, and LV end-systolic volume was increased resulting in a significant reduction of LV ejection fraction (47 ± 6% vs. 70 ± 3%). At weeks 4 and 6, but not at week 2, myocardial [18F]FDG uptake was decreased compared with the control group (respectively, 4.2 ± 0.5%ID/g and 9.2 ± 0.8%ID/g at week 6). Moreover, [18F]FDG cardiac uptake correlated with cardiac function impairment. In contrast, from week 2, a significant decrease of myocardial [123I]MIBG heart to mediastinum ratio was detected in the doxorubicin group and was maintained at weeks 4 and 6 with a 45.6% decrease at week 6. This longitudinal study precises that after doxorubicin treatment, cardiac [123I]MIBG uptake is significantly reduced as early as 2 weeks followed by the decrease of the LV end-diastolic volume and [18F]FDG uptake at 4 weeks and finally by the increase of LV end-systolic volume and decrease of LV ejection fraction at 6 weeks. Cardiac innervation imaging should thus be considered as an early key feature of anthracycline cardiac toxicity. The online version contains supplementary material available at 10.1186/s13550-021-00835-1.
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影响因子：
2.4
作者：
Bauckneht, Matteo;Pastorino, Fabio;Marini, Cecilia
通讯作者：
Marini, Cecilia
影响因子：
6.2
作者：
Gimelli, Alessia;Liga, Riccardo;Slart, Riemer H. J. A.
通讯作者：
Slart, Riemer H. J. A.
DOI：
10.1093/eurheartj/suaa127
发表时间：
2020-11
期刊：
European heart journal supplements : journal of the European Society of Cardiology
影响因子：
--
作者：
Bisceglia I;Cartoni D;Petrolati S
通讯作者：
Petrolati S
DOI：
10.1161/circimaging.115.003584
发表时间：
2016-12
期刊：
Circulation. Cardiovascular imaging
影响因子：
--
作者：
Farhad H;Staziaki PV;Addison D;Coelho-Filho OR;Shah RV;Mitchell RN;Szilveszter B;Abbasi SA;Kwong RY;Scherrer-Crosbie M;Hoffmann U;Jerosch-Herold M;Neilan TG
通讯作者：
Neilan TG
影响因子：
9.3
作者：
Higuchi, Takahiro;Yousefi, Behrooz H.;Nekolla, Stephan G.
通讯作者：
Nekolla, Stephan G.