Micronutrient synergy--a new tool in effective control of metastasis and other key mechanisms of cancer.
Micronutrient synergy--a new tool in effective control of metastasis and other key mechanisms of cancer.
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DOI：
10.1007/s10555-010-9244-1
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发表时间：
2010-09
影响因子：
9.2
通讯作者：
Rath, M.
中科院分区：
文献类型：
--
作者：
Niedzwiecki, A.;Roomi, M. W.;Kalinovsky, T.;Rath, M.
食用植物性饮食与预防癌症的发展和进展有关。我们已经制定了一些策略，通过针对所有类型的癌细胞所使用的降低结缔组织稳定性和完整性的共同机制来抑制癌症的发展和扩散。胶原蛋白和结缔组织的强化可以通过特定营养素的协同作用自然实现，如赖氨酸、脯氨酸、抗坏血酸和绿茶提取物(NM)。这种微量营养素混合物在体内和体外的几十个癌细胞系中都显示出了强大的抗癌活性。其抗癌作用包括抑制转移、抑制肿瘤生长、抑制基质金属蛋白酶(MMPs)分泌、抑制侵袭、抑制血管生成、抑制细胞生长和诱导细胞凋亡。许多癌症通常是在晚期被诊断出来的，那时已经发生了转移，而标准治疗已经无法控制这种情况。我们对NM对肝和肺转移的影响的研究表明，在小鼠模型中，NM对转移有深刻的、显著的抑制作用。在小鼠模型中对NM对异种移植的影响的评估表明，在所有被测试的人类癌细胞系中，肿瘤大小和肿瘤负荷都显著减少。体外研究表明，NM在抑制多种肿瘤细胞系的细胞增殖(通过四甲基偶氮唑盐比色法)、分泌基质金属蛋白酶(通过明胶酶谱)、细胞侵袭(通过Matrigel)、细胞迁移(通过划痕实验)、诱导细胞凋亡(通过活的绿色半胱氨酸天冬氨酸酶)和诱导促凋亡基因方面非常有效。此外，体内和体外对单个微量营养素与其特定组合的效果的比较研究表明，协同效应导致抗癌效力的提高。
Consumption of a plant-based diet has been associated with prevention of the development and progression of cancer. We have developed strategies to inhibit cancer development and its spread by targeting common mechanisms used by all types of cancer cells that decrease stability and integrity of connective tissue. Strengthening of collagen and connective tissue can be achieved naturally through the synergistic effects of selected nutrients, such as lysine, proline, ascorbic acid and green tea extract (NM). This micronutrient mixture has exhibited a potent anticancer activity in vivo and in vitro in a few dozen cancer cell lines. Its anti-cancer effects include inhibition of metastasis, tumor growth, matrix metalloproteinase (MMP) secretion, invasion, angiogenesis, and cell growth as well as induction of apoptosis. Many cancers are often diagnosed at later stages, when metastasis has occurred, which standard treatment has been unable to control. Our studies on NM effects on hepatic and pulmonary metastasis demonstrated profound, significant suppression of metastasis in a murine model. Evaluation of effects of NM on xenografts in murine models demonstrated significant reduction in tumor size and tumor burden in all human cancer cell lines tested. In vitro studies demonstrated that NM was very effective in inhibition of cell proliferation (by MTT assay), MMP secretion (by gelatinase zymography), cell invasion (through Matrigel), cell migration (by scratch test), induction of apoptosis (by live green caspase) and induction of pro-apoptotic genes in many diverse cancer cell lines. Furthermore, in vivo and in vitro studies of effects of individual micronutrients compared to their specific combination demonstrated synergistic effects resulting in improved anticancer potency.
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影响因子：
4.2
作者：
Roomi, M. Waheed;Kalinovsky, Tatiana;Niedzwiecki, Aleksandra
通讯作者：
Niedzwiecki, Aleksandra
影响因子：
2.7
作者：
Harakeh, S.;Diab-Assaf, M.;Rath, M.
通讯作者：
Rath, M.
影响因子：
5.4
作者：
Ivanov, V.;Cha, J.;Niedzwiecki, A.
通讯作者：
Niedzwiecki, A.
影响因子：
3.4
作者：
Ivanov, V.;Ivanova, S.;Rath, M.
通讯作者：
Rath, M.
影响因子：
2.9
作者：
Kale, Anup;Gawande, Sonia;Rath, Matthias
通讯作者：
Rath, Matthias