Image processing and Quality Control for the first 10,000 brain imaging datasets from UK Biobank.

Image processing and Quality Control for the first 10,000 brain imaging datasets from UK Biobank.
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DOI:
10.1016/j.neuroimage.2017.10.034
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发表时间:
2018-02-01
期刊:
影响因子:
5.7
通讯作者:
Smith SM
Smith SM
中科院分区:
医学1区
文献类型:
--
作者:
Alfaro-Almagro F;Jenkinson M;Bangerter NK;Andersson JLR;Griffanti L;Douaud G;Sotiropoulos SN;Jbabdi S;Hernandez-Fernandez M;Vallee E;Vidaurre D;Webster M;McCarthy P;Rorden C;Daducci A;Alexander DC;Zhang H;Dragonu I;Matthews PM;Miller KL;Smith SM

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英国生物库是一项大规模的前瞻性流行病学研究,全世界的研究人员都可以访问所有数据。目前正在将10万名最初的参与者带回接受大脑、心脏和身体核磁共振、颈动脉超声和低剂量骨/脂肪X光检查。脑成像部分包括6种成像方式(T1、T2 FLAIR、磁化率加权MRI、静息功能磁共振、任务功能磁共振和弥散成像)。来自第一批10,000名受试者的原始和经过处理的数据最近已经公布,供一般研究使用。为了帮助将这些数据转换为有用的摘要信息,我们开发了一种自动化处理和质量控制(QC)管道,可供其他研究人员使用。在本文中,我们在简要概述英国生物库脑成像和采集协议的基础上,详细描述了这一流水线。我们还描述了作为成像协议和处理流水线开发的一部分而进行的几项定量调查。
UK Biobank is a large-scale prospective epidemiological study with all data accessible to researchers worldwide. It is currently in the process of bringing back 100,000 of the original participants for brain, heart and body MRI, carotid ultrasound and low-dose bone/fat x-ray. The brain imaging component covers 6 modalities (T1, T2 FLAIR, susceptibility weighted MRI, Resting fMRI, Task fMRI and Diffusion MRI). Raw and processed data from the first 10,000 imaged subjects has recently been released for general research access. To help convert this data into useful summary information we have developed an automated processing and QC (Quality Control) pipeline that is available for use by other researchers. In this paper we describe the pipeline in detail, following a brief overview of UK Biobank brain imaging and the acquisition protocol. We also describe several quantitative investigations carried out as part of the development of both the imaging protocol and the processing pipeline.
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