Diets involved in PPAR and PI3K/AKT/PTEN pathway may contribute to neuroprotection in a traumatic brain injury.
Diets involved in PPAR and PI3K/AKT/PTEN pathway may contribute to neuroprotection in a traumatic brain injury.
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DOI：
10.1186/alzrt208
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Matsuda S
中科院分区：
文献类型：
--
作者：
Kitagishi Y;Matsuda S
创伤性脑病已成为一个重要的公共卫生问题。据信，创伤性脑病是由在神经退行性疾病的初始症状之前暴露于重复性脑创伤引起的。因此，预防对疾病很重要。PI 3 K/AKT/PTEN（10号染色体上缺失的磷酸肌醇-3激酶/AKT/磷酸酶和张力蛋白同源物）途径已显示在神经保护中起关键作用，通过刺激细胞增殖和抑制细胞凋亡来增强细胞存活。PTEN通过其脂质磷酸酶活性负调控PI 3 K/AKT通路。虽然PTEN已被发现是一种肿瘤抑制因子，但它也与其他几种疾病有关，包括糖尿病和阿尔茨海默病。富含多不饱和脂肪酸的鱼油可能通过激活过氧化物酶体增殖物激活受体诱导PTEN表达。补充这些天然化合物可能为大脑疾病提供新的治疗方法。本文综述了近年来有关创伤性脑病的饮食特点和信号通路的研究进展。
Traumatic encephalopathy has emerged as a significant public health problem. It is believed that traumatic encephalopathy is caused by exposure to repetitive brain trauma prior to the initial symptoms of neurodegenerative disease. Therefore, prevention is important for the disease. The PI3K/AKT/PTEN (phosphoinositide-3 kinase/AKT/phosphatase and tensin homologue deleted on chromosome 10) pathway has been shown to play a pivotal role in neuroprotection, enhancing cell survival by stimulating cell proliferation and inhibiting apoptosis. PTEN negatively regulates the PI3K/AKT pathways through its lipid phosphatase activity. Although PTEN has been discovered as a tumor suppressor, PTEN is also involved in several other diseases, including diabetes and Alzheimer’s disease. Dietary fish oil rich in polyunsaturated fatty acids may induce the PTEN expression by activation of peroxisome proliferator-activated receptor. Supplementation of these natural compounds may provide a new therapeutic approach to the brain disorder. We review recent studies on the features of several diets and the signaling pathways involved in traumatic encephalopathy.
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