Mini-review: Trophic interactions between cancer cells and primary afferent neurons.
Mini-review: Trophic interactions between cancer cells and primary afferent neurons.
复制标题
癌细胞和初级传入神经元之间的营养相互作用。
DOI：
10.1016/j.neulet.2021.135658
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发表时间：
2021-02-16
影响因子：
2.5
通讯作者：
Amit M
中科院分区：
文献类型：
--
作者：
Hunt PJ;Andújar FN;Silverman DA;Amit M
癌症神经生物学是一门新兴学科，它不可避免地为肿瘤学带来了新的视角。神经在癌症进展中扮演的角色与长期以来报道的肿瘤对神经分子机制的依赖性产生了共鸣，这些机制仍然不够清楚。尽管神经营养生长因子和受体之间的相互作用在神经系统中已经得到了广泛的研究，但它们在肿瘤中的表达以及它们通过相应的信号通路对肿瘤细胞生长和转移的影响一直被低估。越来越多的证据表明，神经释放的营养因子强烈影响肿瘤的发展，这种神经贡献似乎不仅起到刺激作用，而且作为肿瘤微环境的重要组成部分发挥作用。这种增殖细胞和肿瘤浸润性神经之间的双向交流推动了轴突形成和肿瘤的生长和迁移。更好地了解初级传入神经元和侵袭性肿瘤之间的营养相互作用将指导临床上可操作的策略，以防止肿瘤相关的轴突发生，扰乱神经元和肿瘤之间的化学串扰，最终减少肿瘤的生长和扩散。
Cancer neurobiology is an emerging discipline that inevitably unfurls new perspectives in oncology. The role that nerves play in cancer progression resonates with the long-reported dependency of tumors on neuro-molecular mechanisms that remain insufficiently elucidated. Whereas interactions between neurotrophic growth factors and receptors have been heavily studied in the nervous system, their expression in cancers and their impact on tumor cell growth and metastasis through their corresponding signaling pathways has been undervalued. Accumulating evidence suggests that trophic factors released by nerves strongly influence tumor development and that this neural contribution appears to not only play a stimulatory role but also function as an essential part of the tumor’s microenvironment. This bidirectional communication between proliferating cells and tumor-infiltrating nerves drives axonogenesis and tumor growth and migration. Acquiring a better understanding of the trophic interactions between primary afferent neurons and invading tumors will guide clinically actionable strategies to prevent tumor-associated axonogenesis, disrupting the chemical crosstalk between neurons and tumors and ultimately decreasing tumor growth and spread.
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DOI：
10.1002/pros.23454
发表时间：
2018-03
期刊：
The Prostate
影响因子：
--
作者：
Coarfa C;Florentin D;Putluri N;Ding Y;Au J;He D;Ragheb A;Frolov A;Michailidis G;Lee M;Kadmon D;Miles B;Smith C;Ittmann M;Rowley D;Sreekumar A;Creighton CJ;Ayala G
通讯作者：
Ayala G
影响因子：
5.3
作者：
Boyer NP;Gupton SL
通讯作者：
Gupton SL
影响因子：
5.7
作者：
Guo, Kun;Ma, Qingyong;Xie, Keping
通讯作者：
Xie, Keping
影响因子：
64.8
作者：
Biankin, Andrew V.;Waddell, Nicola;Kassahn, Karin S.;Gingras, Marie-Claude;Muthuswamy, Lakshmi B.;Johns, Amber L.;Miller, David K.;Wilson, Peter J.;Patch, Ann-Marie;Wu, Jianmin;Chang, David K.;Cowley, Mark J.;Gardiner, Brooke B.;Song, Sarah;Harliwong, Ivon;Idrisoglu, Senel;Nourse, Craig;Nourbakhsh, Ehsan;Manning, Suzanne;Wani, Shivangi;Gongora, Milena;Pajic, Marina;Scarlett, Christopher J.;Gill, Anthony J.;Pinho, Andreia V.;Rooman, Ilse;Anderson, Matthew;Holmes, Oliver;Leonard, Conrad;Taylor, Darrin;Wood, Scott;Xu, Qinying;Nones, Katia;Fink, J. Lynn;Christ, Angelika;Bruxner, Tim;Cloonan, Nicole;Kolle, Gabriel;Newell, Felicity;Pinese, Mark;Mead, R. Scott;Humphris, Jeremy L.;Kaplan, Warren;Jones, Marc D.;Colvin, Emily K.;Nagrial, Adnan M.;Humphrey, Emily S.;Chou, Angela;Chin, Venessa T.;Chantrill, Lorraine A.;Mawson, Amanda;Samra, Jaswinder S.;Kench, James G.;Lovell, Jessica A.;Daly, Roger J.;Merrett, Neil D.;Toon, Christopher;Epari, Krishna;Nguyen, Nam Q.;Barbour, Andrew;Zeps, Nikolajs;Kakkar, Nipun;Zhao, Fengmei;Wu, Yuan Qing;Wang, Min;Muzny, Donna M.;Fisher, William E.;Brunicardi, F. Charles;Hodges, Sally E.;Reid, Jeffrey G.;Drummond, Jennifer;Chang, Kyle;Han, Yi;Lewis, Lora R.;Dinh, Huyen;Buhay, Christian J.;Beck, Timothy;Timms, Lee;Sam, Michelle;Begley, Kimberly;Brown, Andrew;Pai, Deepa;Panchal, Ami;Buchner, Nicholas;De Borja, Richard;Denroche, Robert E.;Yung, Christina K.;Serra, Stefano;Onetto, Nicole;Mukhopadhyay, Debabrata;Tsao, Ming-Sound;Shaw, Patricia A.;Petersen, Gloria M.;Gallinger, Steven;Hruban, Ralph H.;Maitra, Anirban;Iacobuzio-Donahue, Christine A.;Schulick, Richard D.;Wolfgang, Christopher L.;Morgan, Richard A.;Lawlor, Rita T.;Capelli, Paola;Corbo, Vincenzo;Scardoni, Maria;Tortora, Giampaolo;Tempero, Margaret A.;Mann, Karen M.;Jenkins, Nancy A.;Perez-Mancera, Pedro A.;Adams, David J.;Largaespada, David A.;Wessels, Lodewyk F. A.;Rust, Alistair G.;Stein, Lincoln D.;Tuveson, David A.;Copeland, Neal G.;Musgrove, Elizabeth A.;Scarpa, Aldo;Eshleman, James R.;Hudson, Thomas J.;Sutherland, Robert L.;Wheeler, David A.;Pearson, John V.;McPherson, John D.;Gibbs, Richard A.;Grimmond, Sean M.
通讯作者：
Grimmond, Sean M.
DOI：
10.4049/jimmunol.1601613
发表时间：
2017-05-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Chavan SS;Tracey KJ
通讯作者：
Tracey KJ