Biology of natural killer cells.
Biology of natural killer cells.
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DOI：
10.1016/s0065-2776(08)60664-1
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发表时间：
1989
影响因子：
--
通讯作者：
Trinchieri G
中科院分区：
文献类型：
--
作者：
Trinchieri G
人类淋巴细胞的细胞毒性研究表明，不仅同种异体和同基因肿瘤细胞在非MHC限制的方式裂解，但也从正常供体的淋巴细胞往往是细胞毒性。在没有已知或故意致敏的情况下，发现来自任何健康供体的淋巴细胞以及来自几只实验动物的外周血和脾淋巴细胞在体外对一些正常新鲜细胞、大多数培养细胞系、未成熟造血细胞和肿瘤细胞具有自发细胞毒性。这种类型的非适应性、非MHC限制性细胞介导的细胞毒性被定义为“天然”细胞毒性，并且介导天然细胞毒性的效应细胞在功能上被定义为自然杀伤（NK）细胞。NK细胞的存在促使人们重新解释对自发性人类肿瘤的特异性细胞毒性研究和免疫监视理论，至少在其最严格的解释中是这样。与细胞毒性T细胞不同，NK细胞不能被证明具有克隆分布的特异性、对靶细胞表面的MHC产物的限制或免疫记忆。NK细胞还不能基于干细胞的确定性鉴定、成熟的独特解剖位置或独特的基因型重排而正式分配到单一谱系。
Studies of cytotoxicity by human lymphocytes revealed not only that both allogeneic and syngeneic tumor cells were lysed in a non-MHC-restricted fashion, but also that lymphocytes from normal donors were often cytotoxic. Lymphocytes from any healthy donor, as well as peripheral blood and spleen lymphocytes from several experimental animals, in the absence of known or deliberate sensitization, were found to be spontaneously cytotoxic in vitro for some normal fresh cells, most cultured cell lines, immature hematopoietic cells, and tumor cells. This type of nonadaptive, non-MHC-restricted cellmediated cytotoxicity was defined as “natural” cytotoxicity, and the effector cells mediating natural cytotoxicity were functionally defined as natural killer (NK) cells. The existence of NK cells has prompted a reinterpretation of both the studies of specific cytotoxicity against spontaneous human tumors and the theory of immune surveillance, at least in its most restrictive interpretation. Unlike cytotoxic T cells, NK cells cannot be demonstrated to have clonally distributed specificity, restriction for MHC products at the target cell surface, or immunological memory. NK cells cannot yet be formally assigned to a single lineage based on the definitive identification of a stem cell, a distinct anatomical location of maturation, or unique genotypic rearrangements.
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影响因子：
64.8
作者：
ANDERSSON, LC;JOKINEN, M;GAHMBERG, CG
通讯作者：
GAHMBERG, CG
DOI：
10.1016/0162-3109(88)90056-2
发表时间：
1988-03-01
期刊：
IMMUNOPHARMACOLOGY
影响因子：
--
作者：
ABLIN, RJ;BARTKUS, JM;GONDER, MJ
通讯作者：
GONDER, MJ
影响因子：
15.9
作者：
ABO, T;RODER, JC;BALCH, CM
通讯作者：
BALCH, CM
DOI：
10.1073/pnas.84.11.3861
发表时间：
1987-06-01
影响因子：
11.1
作者：
ALARCON, B;DEVRIES, J;SPITS, H
通讯作者：
SPITS, H
影响因子：
5.4
作者：
ABO, T;BALCH, CM
通讯作者：
BALCH, CM