Association of Hepatic Steatosis Index and Fatty Liver Index with Carotid Atherosclerosis in Type 2 Diabetes.
Association of Hepatic Steatosis Index and Fatty Liver Index with Carotid Atherosclerosis in Type 2 Diabetes.
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DOI：
10.7150/ijms.62010
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发表时间：
2021
影响因子：
3.6
通讯作者：
Yuan G
中科院分区：
文献类型：
--
作者：
Wang C;Cai Z;Deng X;Li H;Zhao Z;Guo C;Zhang P;Li L;Gu T;Yang L;Zhao L;Wang D;Yuan G
背景/目的：既往研究表明，肝脏脂肪变性指数（HSI）和脂肪肝指数（FLI）可作为非酒精性脂肪肝病（NAFLD）的预测因子。我们研究的目的是确定非侵入性肝脂肪变性指标（HSI 和 FLI）是否与 2 型糖尿病 (T2DM) 的颈动脉粥样硬化相关。方法：这是一项在 T2DM 患者 (n=768) 中进行的横断面研究。通过彩色多普勒超声测量颈动脉内膜中层厚度（CIMT）。 HSI 是根据性别、体重指数 (BMI) 和转氨酶水平计算的。 FLI 基于 BMI、腰围 (WC)、三酰甘油 (TG) 和 g-谷氨酰转移酶 (GGT)。结果：T2DM 患者 HSI 和 FLI 水平升高与 CIMT 水平升高相关。 CIMT 较高的患者比 CIMT 较低的患者具有较高的 HSI（39.10 ± 5.70 vs 36.10 ± 4.18，P < 0.001）和 FLI（46.35（29.96，65.54） vs 36.93（18.7，57.93），P < 0.001）。存在颈动脉斑块的受试者相应地具有较高的 HSI (38.28 ± 5.63 vs 35.69 ± 3.45 P < 0.001) 和 FLI (47.41 (27.77, 66.62) vs 37.19 (17.71, 51.78), P < 0.001)。 HSI（r = 0.343，P < 0.001）和FLI（r = 0.184，P < 0.001）与CIMT呈正相关。在线性回归中，在充分调整代谢危险因素、吸烟和胰岛素抵抗测量后，HSI 和 FLI 与 CIMT 独立相关（HSI：β = 0.011，FLI：β = 0.001，所有 P < 0.01）。此外，逻辑回归分析显示，较高的HSI和FLI对颈动脉粥样硬化风险有影响[HSI：OR（95％CI）：1.174（1.123-1.228），FLI：OR（95％CI）：1.011（1.004-1.019），均P <0.01]。总体而言，在不同年龄和高血压类别中，HSI 和 FLI 值的增加与 CIMT 显着相关（P < 0.05）。结论：当前数据表明 HSI 和 FLI 与 T2DM 颈动脉粥样硬化独立相关。它们可能是评估糖尿病大血管并发症进展的简单而有用的标记。
Background/aim: Previous studies have suggested that the hepatic steatosis index (HSI) and fatty liver index (FLI) can be used as a predictor of non-alcoholic fatty liver disease (NAFLD). The aim of our study was to determine whether non-invasive indices of hepatic steatosis (HSI and FLI) are associated with carotid atherosclerosis in type 2 diabetes mellitus (T2DM). Methods: This was a cross-sectional study conducted in the T2DM patients (n=768). Carotid intima-media thickness (CIMT) was measured by the Color Doppler ultrasound. The HSI was calculated based on gender, body mass index (BMI), and transaminases level. The FLI was based on BMI, waist circumference (WC), triacylglycerols (TG) and g-glutamyl transferase (GGT). Results: Raised HSI and FLI levels was associated with increased CIMT levels in T2DM patients. Patients with greater CIMT had higher HSI (39.10 ± 5.70 vs 36.10 ± 4.18, P < 0.001) and FLI (46.35 (29.96, 65.54) vs 36.93 (18.7, 57.93), P < 0.001) than those with lower CIMT. Subjects with existing carotid plaque had higher HSI (38.28 ± 5.63 vs 35.69 ± 3.45 P < 0.001) and FLI (47.41 (27.77, 66.62) vs 37.19 (17.71, 51.78), P < 0.001) accordingly. HSI (r = 0.343, P < 0.001) and FLI (r = 0.184, P < 0.001) were positively related with the CIMT. In the linear regression, after full adjustment metabolic risk factors, smoking, and measures of insulin resistance, HSI and FLI were independently associated with CIMT (HSI: β = 0.011, FLI: β = 0.001, all P < 0.01). Further, logistic regression analyses showed that higher HSI and FLI had an impact on the risk for carotid atherosclerosis [HSI: OR (95%CI): 1.174 (1.123-1.228), FLI: OR (95%CI): 1.011(1.004-1.019), all P < 0.01]. Overall, increasing values of HSI and FLI were associated with CIMT (P < 0.05) significantly across different categories of age and hypertension. Conclusion: Current data suggest HSI and FLI are independently correlated with carotid atherosclerosis in T2DM. They may be a simple and useful marker for assessing the progression of diabetic macrovascular complications.
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影响因子：
16.2
作者：
American Diabetes Association
通讯作者：
American Diabetes Association
影响因子：
16.2
作者：
Lomonaco R;Bril F;Portillo-Sanchez P;Ortiz-Lopez C;Orsak B;Biernacki D;Lo M;Suman A;Weber MH;Cusi K
通讯作者：
Cusi K
影响因子：
0.9
作者：
Pereira K;Salsamendi J;Casillas J
通讯作者：
Casillas J
影响因子：
5
作者：
Kunutsor, Setor K.;Bakker, Stephan J. L.;Dullaart, Robin P. F.
通讯作者：
Dullaart, Robin P. F.
影响因子：
3
作者：
Guo, Kaifeng;Zhang, Lei;Jia, Weiping
通讯作者：
Jia, Weiping