Increased Risk of Skin Cancer in 1,851 Long-Term Retinoblastoma Survivors.
Increased Risk of Skin Cancer in 1,851 Long-Term Retinoblastoma Survivors.
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DOI：
10.1016/j.jid.2021.05.021
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发表时间：
2021-12
影响因子：
6.5
通讯作者：
Tucker, Margaret A.
中科院分区：
文献类型：
--
作者：
Kleinerman, Ruth A.;Schonfeld, Sara J.;Abramson, David H.;Francis, Jasmine H.;Seddon, Johanna M.;Morton, Lindsay M.;Tucker, Margaret A.
遗传性视网膜母细胞瘤患者有发生皮肤黑色素瘤的风险，但对阳光照射或其他因素的作用知之甚少，对非黑色素瘤皮肤癌（NMSC）的发病率知之甚少。我们调查了1914-2006年诊断的1851例白色长期视网膜母细胞瘤幸存者（1020例遗传性和831例非遗传性）中黑色素瘤和NMSC的发病率。在2016年的随访中，33名遗传性和7名非遗传性幸存者患上了黑色素瘤，26名遗传性和9名非遗传性幸存者患上了NMSC。大多数NMSC位于头部/颈部，而黑色素瘤分布更广泛，其模式与黑色素瘤易感家族相似。对于这两种结果，遗传性幸存者诊断时的中位年龄比非遗传性幸存者年轻约20岁。视网膜母细胞瘤诊断后50年，黑色素瘤和NMSC的遗传性幸存者的累积发病率分别为4.5%和3.7%;非遗传性幸存者的累积发病率分别为0.7%和1.5%。阳光敏感性和表型特征通常不因皮肤癌状态而变化。与非遗传性幸存者相比，遗传性视网膜母细胞瘤幸存者患黑色素瘤和NMSC的风险增加，可能反映了遗传因素。这些在白色视网膜母细胞瘤幸存者中的发现支持了基于共识的建议，即从年轻时开始进行皮肤癌筛查和防晒并长期持续。
Hereditary retinoblastoma patients are at risk for developing cutaneous melanoma, but little is known about the role of sun exposure or other factors, and incidence of non-melanoma skin cancer (NMSC) is poorly understood. We investigated the incidence of melanoma and NMSC in a cohort of 1851 white, long-term retinoblastoma survivors (1020 hereditary and 831 nonhereditary) diagnosed from 1914–2006. During follow-up through 2016, 33 hereditary and 7 nonhereditary survivors developed melanoma, and 26 hereditary and 9 nonhereditary survivors developed NMSC. Most NMSC were on the head/neck whereas melanomas were more broadly distributed with patterns similar to melanoma-prone families. For both outcomes, median age at diagnosis was ~20 years younger among hereditary than nonhereditary survivors. Fifty years following retinoblastoma diagnosis, the cumulative incidence in hereditary survivors was 4.5% for melanoma and 3.7% for NMSC; for nonhereditary survivors, it was 0.7% and 1.5%, respectively. Sun sensitivity and phenotypic characteristics generally did not vary by skin cancer status. Hereditary retinoblastoma survivors have an increased risk for melanoma and NMSC that occurred earlier compared with nonhereditary survivors, likely reflecting genetic factors. These findings among white retinoblastoma survivors support consensus-based recommendations for skin cancer screening and sun protection starting at young ages and continuing long-term.
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影响因子：
45.3
作者：
Kleinerman, Ruth A.;Schonfeld, Sara J.;Morton, Lindsay M.
通讯作者：
Morton, Lindsay M.
影响因子：
8.8
作者：
Schonfeld SJ;Kleinerman RA;Abramson DH;Seddon JM;Tucker MA;Morton LM
通讯作者：
Morton LM
影响因子：
45.3
作者：
Kleinerman, Ruth A.;Yu, Chu-ling;Tucker, Margaret A.
通讯作者：
Tucker, Margaret A.
影响因子：
8.8
作者：
MacCarthy A;Bayne AM;Brownbill PA;Bunch KJ;Diggens NL;Draper GJ;Hawkins MM;Jenkinson HC;Kingston JE;Stiller CA;Vincent TJ;Murphy MF
通讯作者：
Murphy MF
影响因子：
158.5
作者：
GREENE, MH;CLARK, WH;FRASER, MC
通讯作者：
FRASER, MC