Second and subsequent tumours among 1927 retinoblastoma patients diagnosed in Britain 1951-2004.
Second and subsequent tumours among 1927 retinoblastoma patients diagnosed in Britain 1951-2004.
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DOI：
10.1038/bjc.2013.228
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发表时间：
2013-06-25
影响因子：
8.8
通讯作者：
Murphy MF
中科院分区：
文献类型：
--
作者：
MacCarthy A;Bayne AM;Brownbill PA;Bunch KJ;Diggens NL;Draper GJ;Hawkins MM;Jenkinson HC;Kingston JE;Stiller CA;Vincent TJ;Murphy MF
视网膜母细胞瘤是一种儿童眼部肿瘤，以遗传和非遗传形式发生。在可遗传的形式中，存在发展非眼部后续原发性肿瘤（SPT）的倾向。这项研究包括1951年至2004年在英国诊断的1927名视网膜母细胞瘤患者。通过（英国）国家儿童肿瘤登记处进行确定;对病例进行随访，以了解SPT的发生情况。计算标准化发病率比（SIR）。我们在152例患者中发现了169例SPT。SIR分析包括1971年至2009年登记的145例癌症SPT。这些肿瘤发生在132例患者中：在此期间开始时监测的781例遗传性和1075例（假定）非遗传性病例中的112例至少发生了一次登记的SPT。所有肿瘤合并的SIR在遗传性病例中为13.7（95%置信区间11.3-16.5），在非遗传性病例中为1.5（0.9-2.3）。遗传性病例中的主要SPT类型为平滑肌肉瘤（31例; SIR 1018.7（692.2-1446.0））、骨肉瘤（26例; SIR 444.6（290.4-651.4））和皮肤黑色素瘤（12例; SIR 18.6（9.6-32.4））。遗传性视网膜母细胞瘤中发生SPT的风险极高。这对幸存者及其家属的临床后续行动和咨询具有重要意义。
Retinoblastoma is an eye tumour of childhood that occurs in heritable and non-heritable forms. In the heritable form, there is a predisposition to the development of non-ocular subsequent primary tumours (SPTs). This study included 1927 retinoblastoma patients diagnosed in Britain from 1951 to 2004. Ascertainment was through the (UK) National Registry of Childhood Tumours; cases were followed-up for the occurrence of SPTs. Standardised incidence ratios (SIRs) were calculated. We identified 169 SPTs in 152 patients. The SIR analysis included 145 SPTs with cancer registrations from the years 1971 to 2009. These tumours occurred in 132 patients: 112 of the 781 heritable and 20 of the 1075 (presumed) non-heritable cases under surveillance at the start of this period developed at least one registered SPT. The SIRs for all tumours combined were 13.7 (95% confidence interval 11.3–16.5) in heritable cases and 1.5 (0.9–2.3) in non-heritable cases. The main types of SPT in the heritable cases were leiomyosarcoma, (31 cases; SIR 1018.7 (692.2–1446.0)), osteosarcoma (26 cases; SIR 444.6 (290.4–651.4)), and skin melanoma (12 cases; SIR 18.6 (9.6–32.4)). The risk of SPTs in heritable retinoblastoma is extremely high. This has important implications for the clinical follow-up and counselling of survivors and their families.
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影响因子：
4.7
作者：
Francis, Jasmine H.;Kleinerman, Ruth A.;Abramson, David H.
通讯作者：
Abramson, David H.
影响因子：
8.8
作者：
Sasieni, P. D.;Shelton, J.;Ormiston-Smith, N.;Thomson, C. S.;Silcocks, P. B.
通讯作者：
Silcocks, P. B.
影响因子：
10.3
作者：
Fletcher, O;Easton, D;Peto, J
通讯作者：
Peto, J
影响因子：
4.1
作者：
MacCarthy, A.;Bayne, A. M.;Murphy, M. F. G.
通讯作者：
Murphy, M. F. G.
视网膜母细胞瘤患者的第二原发肿瘤。
影响因子：
8.8
作者：
Draper GJ;Sanders BM;Kingston JE
通讯作者：
Kingston JE