Matrix metalloproteinases and descending aortic aneurysms: parity, disparity, and switch.
Matrix metalloproteinases and descending aortic aneurysms: parity, disparity, and switch.
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DOI:
10.1111/j.1540-8191.2011.01315.x
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发表时间:
2012-01
影响因子:
1.6
通讯作者:
Ikonomidis JS
中科院分区:
文献类型:
--
作者:
Theruvath TP;Jones JA;Ikonomidis JS
Central to the pathologic changes in developing aortic aneurysms are alterations in the abundance and activity of proteases, of which the most important for aneurysm production comprise the matrix metalloproteinase (MMP) family. In this review, literature demonstrating the role of MMPs in the development of aortic aneurysms is presented, with emphasis on the parity and disparity between the thoracic and abdominal aorta. Furthermore, the role of embryologic cellular origins and evidence of phenotypic switch will be addressed in terms of how this process alters MMP production during aneurysm development.
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