Matrix metalloproteinases and descending aortic aneurysms: parity, disparity, and switch.

Matrix metalloproteinases and descending aortic aneurysms: parity, disparity, and switch.
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DOI:
10.1111/j.1540-8191.2011.01315.x
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发表时间:
2012-01
影响因子:
1.6
通讯作者:
Ikonomidis JS
Ikonomidis JS
中科院分区:
医学4区
文献类型:
--
作者:
Theruvath TP;Jones JA;Ikonomidis JS

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发展中的主动脉瘤的病理变化的中心是蛋白酶的丰度和活性的改变,其中对动脉瘤产生最重要的包括基质金属蛋白酶(MMP)家族。在这篇综述中,文献证明基质金属蛋白酶在主动脉瘤的发展中的作用,强调的奇偶性和胸主动脉和腹主动脉之间的差距。此外,胚胎细胞起源的作用和表型转换的证据将在此过程中如何改变动脉瘤发展过程中MMP的生产方面得到解决。
Central to the pathologic changes in developing aortic aneurysms are alterations in the abundance and activity of proteases, of which the most important for aneurysm production comprise the matrix metalloproteinase (MMP) family. In this review, literature demonstrating the role of MMPs in the development of aortic aneurysms is presented, with emphasis on the parity and disparity between the thoracic and abdominal aorta. Furthermore, the role of embryologic cellular origins and evidence of phenotypic switch will be addressed in terms of how this process alters MMP production during aneurysm development.
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