The mitotic exit network Mob1p-Dbf2p kinase complex localizes to the nucleus and regulates passenger protein localization.
The mitotic exit network Mob1p-Dbf2p kinase complex localizes to the nucleus and regulates passenger protein localization.
复制标题
有丝分裂出口网络 Mob1p-Dbf2p 激酶复合物定位于细胞核并调节过客蛋白定位。
DOI：
10.1091/mbc.e05-04-0337
复制
发表时间：
2005
影响因子：
3.3
通讯作者：
Luca,FrancisC
中科院分区：
文献类型：
--
作者：
Stoepel,Jan;Ottey,MichelleA;Kurischko,Cornelia;Hieter,Philip;Luca,FrancisC
TheSaccharomyces cerevisiaemitotic exit network (MEN) is a conserved signaling network that coordinates CDK inactivation, cytokinesis and G1 gene transcription. The MEN Cdc14p phosphatase is sequestered in the nucleolus and transiently released in early anaphase and telophase. Cdc14p mediates mitotic exit by dephosphorylating Cdk1p substrates and promoting Cdk1p inactivation. Cdc14p also regulates the localization of chromosomal passenger proteins, which redistribute from kinetochores to the mitotic spindle during anaphase. Here we present evidence that the MEN protein kinase complex Mob1p-Dbf2p localizes to mitotic nuclei and partially colocalizes with Cdc14p and kinetochore proteins. Chromatin immunoprecipitation (ChIP) experiments reveal that Mob1p, Dbf2p, and Cdc14p associate with centromere DNA and require the centromere binding protein Ndc10p for this association. We establish that Mob1p is essential for maintaining the localization of Aurora, INCENP, and Survivin chromosomal passenger proteins on anaphase spindles, whereas Cdc14p and the Mob1p-Dbf2p-activating kinase Cdc15p are required for establishing passenger protein localization on the spindle. Moreover, Mob1p, but not Cdc15p, is required for dissociating Aurora from the kinetochore region. These findings reveal kinetochores as sites for MEN signaling and implicate MEN in coordinating chromosome segregation and/or spindle integrity with mitotic exit and cytokinesis via regulation of chromosome passenger proteins.
登录
查看更多内容
人粘膜地址素细胞粘附分子-1优先在肠道和相关淋巴组织中表达。
DOI：
--
发表时间：
1997
期刊：
The American journal of pathology
影响因子：
--
作者：
Briskin,M;Winsor-Hines,D;Shyjan,A;Cochran,N;Bloom,S;Wilson,J;McEvoy,LM;Butcher,EC;Kassam,N;Mackay,CR;Newman,W;Ringler,DJ
通讯作者：
Ringler,DJ
影响因子：
4.4
作者：
A. Hamann;D. Andrew;D. Jablonski‐Westrich;B. Holzmann;E. Butcher
通讯作者：
A. Hamann;D. Andrew;D. Jablonski‐Westrich;B. Holzmann;E. Butcher
肠恶性淋巴瘤息肉病中黏膜归巢受体α4β7的表达
影响因子：
29.4
作者：
S. Pals;P. Drillenburg;B. Dragosics;A. Lazarovits;T. Radaszkiewicz
通讯作者：
T. Radaszkiewicz
人类循环淋巴细胞的归巢潜力取决于激活部位：口服伤寒疫苗（而非肠胃外注射）会诱导循环抗体分泌细胞，这些细胞都带有将其引导至肠道的归巢受体。
DOI：
--
发表时间：
1997
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Kantele,A;Kantele,JM;Savilahti,E;Westerholm,M;Arvilommi,H;Lazarovits,A;Butcher,EC;Mäkelä,PH
通讯作者：
Mäkelä,PH
使用通过免疫组织化学染色组织切片显微切割获得的 DNA 证明人结肠粘膜 T 细胞的局部克隆性
影响因子：
5.4
作者：
A. Doğan;D. Dunn;T. T. MacDonald;J. Spencer
通讯作者：
J. Spencer