Expression of the mucosal homing receptor α4β7 in malignant lymphomatous polyposis of the intestine

Expression of the mucosal homing receptor α4β7 in malignant lymphomatous polyposis of the intestine
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肠恶性淋巴瘤息肉病中黏膜归巢受体α4β7的表达

DOI:
10.1016/0016-5085(94)90558-4
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发表时间:
1994
期刊:
影响因子:
29.4
通讯作者:
T. Radaszkiewicz
T. Radaszkiewicz
中科院分区:
医学1区
文献类型:
--
作者:
S. Pals;P. Drillenburg;B. Dragosics;A. Lazarovits;T. Radaszkiewicz

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Recent studies have identified the integrin α4β7 as a mucosal homing receptor that mediates lymphocyte migration to the intestinal mucosa by binding to MAdCAM-1, which is a vascular recognition molecule (adressin) selectively expressed on mucosal endothelium. The expression of the α4β7 mucosal homing receptor was studied in eight cases of malignant lymphomatous polyposis (MLP). This unusual presentation of non-Hodgkin's lymphoma of mantle cell type is characterized by multifocal lymphomatous involvement of the gastrointestinal tract. Unlike nodal mantle cell lymphomas, cases of MLP showed expression of α4β7, suggesting that this homing receptor plays an important role in determining the characteristic mucosal dissemination pattern of MLP.
单克隆抗体 HECA-452 定义了人淋巴组织和炎症组织中的高内皮分化。
DOI: --
发表时间: 1988
期刊: The American journal of pathology
影响因子: --
作者:
Duijvestijn,AM;Horst,E;Pals,ST;Rouse,BN;Steere,AC;Picker,LJ;Meijer,CJ;Butcher,EC
通讯作者: Butcher,EC
DOI: 10.1146/annurev.iy.10.040192.003021
发表时间: 1992
影响因子: 29.7
作者:
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通讯作者: L. Picker;E. Butcher
DOI: 10.4049/jimmunol.137.4.1270
发表时间: 1986-08
影响因子: 4.4
作者:
R. Rothlein;Michael Loran Dustin;S. D. Marlin;T. Springer
通讯作者: R. Rothlein;Michael Loran Dustin;S. D. Marlin;T. Springer
DOI: --
发表时间: 1990
期刊: The American journal of pathology
影响因子: --
作者:
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通讯作者: L. Picker;S. Michie;L. Rott;E. Butcher
DOI: --
发表时间: 1984
期刊: Journal of immunology (Baltimore, Md. : 1950)
影响因子: --
作者:
Lazarovits,AI;Moscicki,RA;Kurnick,JT;Camerini,D;Bhan,AK;Baird,LG;Erikson,M;Colvin,RB
通讯作者: Colvin,RB