Application progress of plant-mediated RNAi in pest control.
Application progress of plant-mediated RNAi in pest control.
复制标题
植物介导的RNAi在害虫防治中的应用进展
DOI：
10.3389/fbioe.2022.963026
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发表时间：
2022
影响因子：
5.7
通讯作者：
An, Shiheng
中科院分区：
文献类型：
--
作者：
Li, Xiang;Liu, Xiaoguang;Lu, Wenhui;Yin, Xinming;An, Shiheng
关键词：
基于RNA干扰（RNAi）的生物农药是利用RNAi原理开发的新型生物产品。它们被改造成农业疾病、昆虫和杂草的靶基因，干扰它们的靶基因表达，从而阻碍它们的生长并减轻它们对作物的破坏作用。基于RNAi的生物农药大致分为抗性植物基植物掺入保护剂（PIP）和非植物掺入保护剂。基于PIP RNAi的生物农药是联合收割机RNAi和抗性转基因作物优点的新型生物农药。此类基于RNAi的生物农药通过核或质体转化来培育抗性植物，即，表达dsRNA的转基因植物。靶基因的dsRNA在植物细胞中表达，通过植物-靶生物相互作用实现害虫和疾病控制。本文综述了RNA干扰在害虫治理中的作用机制和策略、基于RNA干扰的转基因植物的发展、利用这些产品进行害虫治理的现状和优势，以及未来的研究方向和生产和商业化中存在的问题。本研究旨在阐明基于RNAi的生物农药的发展现状，并为未来的研究提供指导。
RNA interference (RNAi)-based biopesticides are novel biologic products, developed using RNAi principles. They are engineered to target genes of agricultural diseases, insects, and weeds, interfering with their target gene expression so as to hinder their growth and alleviate their damaging effects on crops. RNAi-based biopesticides are broadly classified into resistant plant-based plant-incorporated protectants (PIPs) and non-plant-incorporated protectants. PIP RNAi-based biopesticides are novel biopesticides that combine the advantages of RNAi and resistant transgenic crops. Such RNAi-based biopesticides are developed through nuclear or plastid transformation to breed resistant plants, i.e., dsRNA-expressing transgenic plants. The dsRNA of target genes is expressed in the plant cell, with pest and disease control being achieved through plant-target organism interactions. Here, we review the action mechanism and strategies of RNAi for pest management, the development of RNAi-based transgenic plant, and the current status and advantages of deploying these products for pest control, as well as the future research directions and problems in production and commercialization. Overall, this study aims to elucidate the current development status of RNAi-based biopesticides and provide guidelines for future research.
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