Critical roles for SoxC transcription factors in development and cancer.
Critical roles for SoxC transcription factors in development and cancer.
复制标题
DOI：
10.1016/j.biocel.2009.07.018
复制
发表时间：
2010-03
影响因子：
4
通讯作者：
Penzo-Mendez, Alfredo I.
中科院分区：
文献类型：
--
作者：
Penzo-Mendez, Alfredo I.
Sox 4、Sox 11和Sox 12构成了Sry相关HMG box蛋白的C组。它们在胚胎神经元祖细胞和许多发育器官的间充质细胞中共表达。与其他蛋白质相比，它们之间的关系更为密切，但它们在体外结合DNA并以不同的效率激活转录。Sox4缺失的胚胎和Sox11缺失的新生儿死于心脏畸形，后者显示出广泛的缺陷，而Sox12缺失的小鼠是可行的，没有显示出明显的畸形。Sox 4促进淋巴细胞、胰腺β细胞、成骨细胞的分化，并与Sox 11冗余地起作用以促进神经元分化。Sox4和Sox11在人类的许多肿瘤类型中上调，它们在细胞存活、增殖和转移中的作用仍然存在争议。总之，这些数据表明，Sox 4和Sox 11调节细胞分化，增殖和生存在多个重要的过程，并建议他们可能会采取行动，冗余控制更多的发育，生理和病理过程比目前已知的。
Sox4, Sox11 and Sox12 constitute the group C of Sry-related HMG box proteins. They are co-expressed in embryonic neuronal progenitors and in mesenchymal cells in many developing organs. More closely related to each other than to any other proteins, they nevertheless bind DNA and activate transcription in vitro with different efficiencies. Sox4-null embryos and Sox11-null newborns die from heart malformations and the latter display widespread defects, while Sox12-null mice are viable and do not show obvious malformations. Sox4 facilitates differentiation of lymphocytes, pancreatic beta cells, osteoblasts and acts in redundancy with Sox11 to promote neuronal differentiation. Sox4 and Sox11 are upregulated in many tumor types in humans, where their roles in cell survival, proliferation, and metastasis remain controversial. Together, these data hint that Sox4 and Sox11 regulate cell differentiation, proliferation and survival in multiple essential processes, and suggest that they may act in redundancy to control many more developmental, physiological and pathological processes than currently known.
登录
查看更多内容
影响因子：
10.5
作者：
Bergsland, Maria;Werme, Martin;Muhr, Jonas
通讯作者：
Muhr, Jonas
DNA 损伤诱导 SOX4 对于 p53 稳定和功能至关重要
DOI：
10.1073/pnas.0810147106
发表时间：
2009-03-10
影响因子：
11.1
作者：
Pan, Xin;Zhao, Jie;Zhang, Xue-Min
通讯作者：
Zhang, Xue-Min
影响因子：
3.5
作者：
Medina, Pedro P.;Castillo, Sandra D.;Sanchez-Cespedes, Montse
通讯作者：
Sanchez-Cespedes, Montse
影响因子：
3.5
作者：
Maschhoff, KL;Anziano, PQ;Baldwin, HS
通讯作者：
Baldwin, HS
影响因子：
5.3
作者：
Tanaka, S;Kamachi, Y;Kondoh, H
通讯作者：
Kondoh, H