The effects of female sex, viral genotype, and IL28B genotype on spontaneous clearance of acute hepatitis C virus infection.
The effects of female sex, viral genotype, and IL28B genotype on spontaneous clearance of acute hepatitis C virus infection.
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DOI：
10.1002/hep.26639
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发表时间：
2014-01
期刊：
影响因子：
13.5
通讯作者：
Prins, Maria
中科院分区：
文献类型：
--
作者：
Grebely, Jason;Page, Kimberly;Sacks-Davis, Rachel;van der Loeff, Maarten Schim;Rice, Thomas M.;Bruneau, Julie;Morris, Meghan D.;Hajarizadeh, Behzad;Amin, Janaki;Cox, Andrea L.;Kim, Arthur Y.;McGovern, Barbara H.;Schinkel, Janke;George, Jacob;Shoukry, Naglaa H.;Lauer, Georg M.;Maher, Lisa;Lloyd, Andrew R.;Hellard, Margaret;Dore, Gregory J.;Prins, Maria
尽管20-40%的急性HCV感染者表现出自发清除，但与清除相关的时间过程和因素仍然知之甚少。我们采用考克斯比例风险分析研究了急性HCV感染者的自发清除时间和预测因素。本分析的数据来自9个前瞻性队列的国际合作，评估急性HCV感染后的结局。在632例急性HCV感染者中，35%为女性，82%为白人，49%为IL 28 B CC基因型（rs 12979860），96%曾注射毒品，47%感染HCV基因型1，5%合并HIV感染。28%在急性HCV检测时为HCV抗体阴性/RNA阳性（早期急性HCV）。在随访期间，632例患者中有173例发生了自发清除，在感染后1年，25%（95%CI：21%，29%）的患者清除了病毒。在清除的患者中，中位清除时间为16.5周（IQR：10.5，33.4周），34%、67%和83%的患者在3个月、6个月和12个月时清除。校正年龄后，与自发清除时间独立相关的因素包括女性[校正风险比（AHR）2.16; 95%CI 1.48，3.18]、IL 28 B CC基因型（vs. CT/TT，AHR 2.26; 95%CI 1.52，3.34）和HCV基因型1（vs.非基因型1，AHR 1.56; 95%CI 1.06，2.30）。IL 28 B基因型和HCV基因型对自发清除率的影响在女性中比男性更大。女性、有利的IL 28 B基因型和HCV基因型1是自发清除的独立预测因素。需要进一步的研究来阐明观察到的基于性别的HCV控制差异。
Although 20–40% of persons with acute HCV infection demonstrate spontaneous clearance, the time-course and factors associated with clearance remain poorly understood. We investigated the time to spontaneous clearance and predictors among participants with acute HCV using Cox proportional hazards analyses. Data for this analysis were drawn from an international collaboration of nine prospective cohorts evaluating outcomes following acute HCV infection. Among 632 participants with acute HCV, 35% were female, 82% were Caucasian, 49% had IL28B CC genotype (rs12979860), 96% had injected drugs ever, 47% were infected with HCV genotype 1 and 5% had HIV co-infection. Twenty-eight percent were HCV antibody negative/RNA positive at the time of acute HCV detection (early acute HCV). During follow-up, spontaneous clearance occurred in 173 of 632 and at one year following infection, 25% (95%CI: 21%, 29%) had cleared virus. Among those with clearance, the median time to clearance was 16.5 weeks (IQR: 10.5, 33.4 weeks), with 34%, 67% and 83% demonstrating clearance at three, six and twelve months. Adjusting for age, factors independently associated with time to spontaneous clearance included female sex [adjusted hazards ratio (AHR) 2.16; 95%CI 1.48, 3.18], IL28B CC genotype (vs. CT/TT, AHR 2.26; 95%CI 1.52, 3.34), and HCV genotype 1 (vs. non-genotype 1, AHR 1.56; 95%CI 1.06, 2.30). The effect of IL28B genotype and HCV genotype on spontaneous clearance was greater among females compared to males. Female sex, favorable IL28B genotype and HCV genotype 1 are independent predictors of spontaneous clearance. Further research is required to elucidate the observed sex-based differences in HCV control.
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影响因子：
13.5
作者：
Grebely, Jason;Petoumenos, Kathy;Hellard, Margaret;Matthews, Gail V.;Suppiah, Vijayaprakash;Applegate, Tanya;Yeung, Barbara;Marks, Phillipa;Rawlinson, William;Lloyd, Andrew R.;Booth, David;Kaldor, John M.;George, Jacob;Dore, Gregory J.
通讯作者：
Dore, Gregory J.
影响因子：
25.7
作者：
van de Laar, Thijs J. W.;Molenkamp, Richard;Bruisten, Sylvia M.
通讯作者：
Bruisten, Sylvia M.
影响因子：
13.5
作者：
Hofer, H;Watkins-Riedel, T;Ferenci, P
通讯作者：
Ferenci, P
DOI：
10.1016/s1473-3099(10)70049-9
发表时间：
2010-05
期刊：
The Lancet. Infectious diseases
影响因子：
--
作者：
Klein SL;Jedlicka A;Pekosz A
通讯作者：
Pekosz A
影响因子：
11.8
作者：
Cox, AL;Netski, DM;Thomas, DL
通讯作者：
Thomas, DL