Pigmentation pathway evolution after whole-genome duplication in fish.
Pigmentation pathway evolution after whole-genome duplication in fish.
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DOI：
10.1093/gbe/evp050
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发表时间：
2009-11-25
影响因子：
3.3
通讯作者：
Schartl M
中科院分区：
文献类型：
--
作者：
Braasch I;Brunet F;Volff JN;Schartl M
全基因组复制（WGD）在脊椎动物中反复发生 谱系，但其表型进化的进化意义仍然存在 难以捉摸。在这里，我们研究了鱼类特异性基因组的影响， 复制（FSGD）对硬骨鱼色素沉着途径的进化。 色素和颜色图案是硬骨鱼类最多样化的特征之一， 它们的色素系统是所有脊椎动物中最复杂的。使用比较基因组方法，包括系统发育和同线分析， 五种硬骨鱼基因组中128个脊椎动物色素基因的进化 之后，FSGD被重建。我们发现色素沉着基因 在FSGD后优先保留一式两份，因此硬骨鱼类 与四足动物相比色素基因多30%。这明显 高于硬骨鱼FSGD基因重复保留的全基因组估计值。 黑素细胞调节网络的大部分保留在两个 FSGD后的副本。重复的色素沉着基因遵循一般的进化 模式，如蛋白质复合物化学计量的保存和 发育基因在保留的重复中的过度表达。这些 结果表明，FSGD对 硬骨鱼特有的色素沉着特征的进化，其中包括新的 色素细胞类型或现有色素细胞类型分裂成不同的 亚型此外，我们还观察到， 重复的保留和进化可能有助于猪的多样性 在硬骨鱼中。因此，我们的研究强烈支持WGD促进了 脊椎动物表型进化过程中复杂性和多样性的增加。
Whole-genome duplications (WGDs) have occurred repeatedly in the vertebrate lineage, but their evolutionary significance for phenotypic evolution remains elusive. Here, we have investigated the impact of the fish-specific genome duplication (FSGD) on the evolution of pigmentation pathways in teleost fishes. Pigmentation and color patterning are among the most diverse traits in teleosts, and their pigmentary system is the most complex of all vertebrate groups. Using a comparative genomic approach including phylogenetic and synteny analyses, the evolution of 128 vertebrate pigmentation genes in five teleost genomes following the FSGD has been reconstructed. We show that pigmentation genes have been preferentially retained in duplicate after the FSGD, so that teleosts have 30% more pigmentation genes compared with tetrapods. This is significantly higher than genome-wide estimates of FSGD gene duplicate retention in teleosts. Large parts of the melanocyte regulatory network have been retained in two copies after the FSGD. Duplicated pigmentation genes follow general evolutionary patterns such as the preservation of protein complex stoichiometries and the overrepresentation of developmental genes among retained duplicates. These results suggest that the FSGD has made an important contribution to the evolution of teleost-specific features of pigmentation, which include novel pigment cell types or the division of existing pigment cell types into distinct subtypes. Furthermore, we have observed species-specific differences in duplicate retention and evolution that might contribute to pigmentary diversity among teleosts. Our study therefore strongly supports the hypothesis that WGDs have promoted the increase of complexity and diversity during vertebrate phenotypic evolution.
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影响因子：
4.5
作者：
Bridgham, Jamie T.;Brown, Justine E.;Rodriguez-Mari, Adriana;Catchen, Julian M.;Thornton, Joseph W.
通讯作者：
Thornton, Joseph W.
影响因子：
56.9
作者：
BAGNARA, JT;MATSUMOTO, J;TAYLOR, JD
通讯作者：
TAYLOR, JD
影响因子：
4.3
作者：
Braasch, Ingo;Liedtke, Daniel;Schartl, Manfred
通讯作者：
Schartl, Manfred
影响因子：
10.7
作者：
Brunet, Frederic G.;Roest Crollius, Hugues;Robinson-Rechavi, Marc
通讯作者：
Robinson-Rechavi, Marc
影响因子：
64.8
作者：
Aury, Jean-Marc;Jaillon, Olivier;Wincker, Patrick
通讯作者：
Wincker, Patrick