Kinetics of viral load and cytokines in severe fever with thrombocytopenia syndrome.
Kinetics of viral load and cytokines in severe fever with thrombocytopenia syndrome.
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DOI：
10.1016/j.jcv.2018.01.017
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发表时间：
2018-04
期刊：
影响因子：
--
通讯作者：
Kim SH
中科院分区：
文献类型：
--
作者：
Kwon JS;Kim MC;Kim JY;Jeon NY;Ryu BH;Hong J;Kim MJ;Chong YP;Lee SO;Choi SH;Kim YS;Woo JH;Kim SH
SFTS病毒血症从症状出现之日起持续到第3周。SFTS患者炎性细胞因子浓度升高。干扰素-α、IL-10和IP-10与最初的细胞因子风暴有关。重症发热伴血小板减少综合征(SFTS)是中国、日本和韩国的一种新发传染病，以高热、血小板减少、病死率高为主要特征。假设细胞因子风暴在SFT的病理生理学中起重要作用。然而，关于病毒载量和细胞因子在整个疾病过程中的详细动力学的数据有限。我们研究了SFTS患者细胞因子和病毒载量的变化模式。入院期间，从血浆中提取RNA，用逆转录聚合酶链式反应进行定量。此外，对所选的18种细胞因子和趋化因子进行了细胞因子珠阵列的检测。从入院到SFTS病毒血症阴转的中位时间为17.0 d。当接受审查的患者在出院时被发现病毒载量为阴性时，病毒脱落的中位持续时间为13.0 天(95%可信区间，5.4-20.6)。干扰素-α、白介素10和干扰素-γ诱导蛋白(IP)-10的浓度在疾病早期显著升高，然后在住院期间下降。而肿瘤坏死因子-α、IL-1β、IL-12p40、IL-13、IL-17A、活化调节T细胞表达和分泌正常T细胞(RANTES)、血管内皮生长因子(VEGFR)在病程晚期升高。入院第1-4天的初始IP-10水平与初始病毒载量的相关性最显著(r = 0.88，P <； .01)。SFTS病毒血症持续至2-3周，且与初始血浆IP-10水平高度相关。此外，干扰素-α、IL-10和IP-10与SFT最初的细胞因子风暴有关。
SFTS viremia persists until week 3 from the day of symptom onset. The concentrations of inflammatory cytokines are elevated in SFTS patients. IFN-α, IL-10, and IP-10 are associated with the initial cytokine storm. Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease in China, Japan, and Korea, which is characterized by high fever, thrombocytopenia, and high mortality. It is hypothesized that a cytokine storm plays an important role in the pathophysiology of SFTS. However, limited data have been published on the detailed kinetics of the viral load and cytokine profiles throughout the course of this disease. We investigated the patterns of changes in cytokines and viral load in SFTS patients. During the admission period of patients, RNA was extracted from plasma and quantified by reverse transcription polymerase chain reaction. In addition, cytokine bead arrays were performed for the 18 cytokines and chemokines selected for testing. The median time from admission to the negative conversion of SFTS viremia was 17.0 days. When censored patients were found to be negative for viral load at discharge, the median duration of viral shedding was 13.0 days (95% CI, 5.4–20.6). Interferon (IFN)-α, interleukin (IL)-10, and IFN-γ-induced protein (IP)-10 concentrations significantly increased in the early course of disease and then decreased during the hospital stay. However, the concentrations of tumor necrosis factor-α, IL-1β, IL-12p40, IL-13, IL-17A, Regulated on Activation and Normally T-cell Expressed and Secreted (RANTES), and vascular endothelial growth factor (VEGF) increased during the late course of disease. Initial IP-10 levels during hospital days 1–4 were the most significantly correlated with initial viral load (r = 0.88, P < .01). SFTS viremia persisted until weeks 2–3 and was highly correlated with initial plasma IP-10 levels. In addition, IFN-α, IL-10, and IP-10 were associated with the initial cytokine storm in SFTS.
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影响因子：
11.8
作者：
Wen HL;Zhao L;Zhai S;Chi Y;Cui F;Wang D;Wang L;Wang Z;Wang Q;Zhang S;Liu Y;Yu H;Yu XJ
通讯作者：
Yu XJ
发热伴血小板减少综合征患者免疫功能的检测与评价
影响因子：
4.6
作者：
Sun L;Hu Y;Niyonsaba A;Tong Q;Lu L;Li H;Jie S
通讯作者：
Jie S
影响因子：
11.8
作者：
Zhang, Yong-Zhen;He, Yong-Wen;Xu, Jianguo
通讯作者：
Xu, Jianguo
中国一种新型布尼亚病毒引起的发热伴血小板减少症。
DOI：
10.1056/nejmoa1010095
发表时间：
2011-04-21
期刊：
The New England journal of medicine
影响因子：
--
作者：
Yu XJ;Liang MF;Zhang SY;Liu Y;Li JD;Sun YL;Zhang L;Zhang QF;Popov VL;Li C;Qu J;Li Q;Zhang YP;Hai R;Wu W;Wang Q;Zhan FX;Wang XJ;Kan B;Wang SW;Wan KL;Jing HQ;Lu JX;Yin WW;Zhou H;Guan XH;Liu JF;Bi ZQ;Liu GH;Ren J;Wang H;Zhao Z;Song JD;He JR;Wan T;Zhang JS;Fu XP;Sun LN;Dong XP;Feng ZJ;Yang WZ;Hong T;Zhang Y;Walker DH;Wang Y;Li DX
通讯作者：
Li DX
影响因子：
8.8
作者：
Yang, Zhen-Dong;Hu, Jian-Gong;Cao, Wu-Chun
通讯作者：
Cao, Wu-Chun