Detection and evaluation of immunofunction of patients with severe fever with thrombocytopenia syndrome.
Detection and evaluation of immunofunction of patients with severe fever with thrombocytopenia syndrome.
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发热伴血小板减少综合征患者免疫功能的检测与评价
DOI：
10.1007/s10238-013-0259-0
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发表时间：
2014-11
影响因子：
4.6
通讯作者：
Jie S
中科院分区：
文献类型：
--
作者：
Sun L;Hu Y;Niyonsaba A;Tong Q;Lu L;Li H;Jie S
发热伴血小板减少综合征（SFTS）是由SFTS病毒（SFTSV）引起的一种新发传染病，病死率高。但免疫功能尚不清楚。本研究的目的是评估SFTS患者的免疫功能。采用流式细胞术检测34例SFTS患者和20例健康献血员的外周血中CD3+、CD4+、CD8+ T淋巴细胞、B细胞和NK细胞的免疫功能。结果表明，SFTS患者外周血中CD 3+、CD 4 + T淋巴细胞明显减少。相反，NK细胞的百分比升高。进一步分析显示，与恢复期和轻度SFTS感染患者相比，急性期和重度SFTS感染患者的CD3+和CD4+ T淋巴细胞数量显示出更强的抑郁模式。但NK细胞在急性期和重症SFTS时明显升高。恢复期恢复至接近正常水平。与存活组相比，死亡组CD 3+、CD 4 + T淋巴细胞水平进行性降低，而B细胞水平升高。SFTSV感染患者免疫系统损害明显，免疫功能紊乱可能是SFTSV感染患者病情进展的部分原因。
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by SFTS virus (SFTSV) with a high fatality rate. But the immunofunction was still unclear. The objective of our study was to assess the immunofunction in SFTS patients. Immunofunction test with flow cytometry which contains CD3+, CD4+ and CD8+ T lymphocytes, B cells and NK cells would be used for detecting serum samples collected from 34 SFTS cases and 20 healthy donors. We found that CD3+ and CD4+ T lymphocytes were significantly diminished in SFTS compared to normal control. In contrast, the percentage of NK cells was elevated. Further analysis revealed that the number of CD3+ and CD4+ T lymphocytes showed that there was a more robust pattern of depression in acute phase and severe SFTS infection compared to the patients in recovery phase and mild SFTS infection. But NK cells were significantly increased in acute phase and severe SFTS. They reverted to the near normal levels in convalescent phase. Additionally, the levels of CD3+ and CD4+ T lymphocytes progressively decreased in death group when compared with the survival group, but the level of B cells was higher. The damages of immune system were obvious, and the immune dysfunction might be partly responsible for disease progression of patients with SFTSV infection.
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影响因子：
4.4
作者：
Pepin M;Bouloy M;Bird BH;Kemp A;Paweska J
通讯作者：
Paweska J
影响因子：
5.4
作者：
Ye, Ye;Hauns, Kevin;Hogue, Brenda G.
通讯作者：
Hogue, Brenda G.
影响因子：
11.8
作者：
Zhang, Yong-Zhen;He, Yong-Wen;Xu, Jianguo
通讯作者：
Xu, Jianguo
影响因子：
5
作者：
Frieman, Matthew;Heise, Mark;Baric, Ralph
通讯作者：
Baric, Ralph
中国一种新型布尼亚病毒引起的发热伴血小板减少症。
DOI：
10.1056/nejmoa1010095
发表时间：
2011-04-21
期刊：
The New England journal of medicine
影响因子：
--
作者：
Yu XJ;Liang MF;Zhang SY;Liu Y;Li JD;Sun YL;Zhang L;Zhang QF;Popov VL;Li C;Qu J;Li Q;Zhang YP;Hai R;Wu W;Wang Q;Zhan FX;Wang XJ;Kan B;Wang SW;Wan KL;Jing HQ;Lu JX;Yin WW;Zhou H;Guan XH;Liu JF;Bi ZQ;Liu GH;Ren J;Wang H;Zhao Z;Song JD;He JR;Wan T;Zhang JS;Fu XP;Sun LN;Dong XP;Feng ZJ;Yang WZ;Hong T;Zhang Y;Walker DH;Wang Y;Li DX
通讯作者：
Li DX