Experimental tools to study molecular recognition within the nanoparticle corona.

Experimental tools to study molecular recognition within the nanoparticle corona.
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DOI:
10.3390/s140916196
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发表时间:
2014-09-02
期刊:
Sensors (Basel, Switzerland)
影响因子:
--
通讯作者:
Strano MS
Strano MS
中科院分区:
其他
文献类型:
--
作者:
Landry MP;Kruss S;Nelson JT;Bisker G;Iverson NM;Reuel NF;Strano MS

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光学纳米传感器开发的进步,使传感器的设计,使用syntheticmolecular recognition元素,通过最近开发的方法称为电晕相分子识别(CoPhMoRe)。从这些设计原理产生的合成传感器对特定分析物具有高度选择性,并且在各种条件下使用时表现出显着的稳定性。纳米传感器开发的一个基本要素取决于理解纳米颗粒和纳米传感器周围相关电晕相之间的界面的能力,这是一种传统表征工具(如NMR)范围之外的环境。这篇综述讨论了需要新的策略和仪器来研究纳米粒子冠,在体外和体内环境中操作。仪器的方法必须有能力同时监测纳米传感器的操作和电晕阶段的分子变化。为未来的应用提供了一个详细的概述新的工具,用于了解CoPhMoRe机制。
Advancements in optical nanosensor development have enabled the design of sensors using syntheticmolecular recognition elements through a recently developed method called Corona Phase MolecularRecognition (CoPhMoRe). The synthetic sensors resulting from these design principles are highly selective for specific analytes, and demonstrate remarkable stability for use under a variety of conditions. An essential element of nanosensor development hinges on the ability to understand the interface between nanoparticles and the associated corona phase surrounding the nanosensor, an environment outside of the range of traditional characterization tools, such as NMR. This review discusses the need for new strategies and instrumentation to study the nanoparticle corona, operating in both in vitro and in vivo environments. Approaches to instrumentation must have the capacity to concurrently monitor nanosensor operation and the molecular changes in the corona phase. A detailed overview of new tools for the understanding of CoPhMoRe mechanisms is provided for future applications.
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