The Influence of Radiological "Disappearing Lesions" on the Efficacy and Prognosis of Patients with Colorectal Liver Metastases Undergoing Conversion Therapy.
The Influence of Radiological "Disappearing Lesions" on the Efficacy and Prognosis of Patients with Colorectal Liver Metastases Undergoing Conversion Therapy.
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DOI：
10.1155/2022/2200598
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发表时间：
2022
影响因子：
2
通讯作者：
Cheng Y
中科院分区：
文献类型：
--
作者：
Song ZY;Yang D;Liu Y;Cheng Y
本研究的目的是分析放射学“消失的肝转移”（DLM）对接受转换治疗的结直肠癌肝转移（CRLM）患者的疗效和预后的影响。 回顾性入组2014年1月至2021年1月重庆医科大学附属第一医院多学科团队（MDT）诊断的CRLM患者。分析DLM的发生、复发与不同临床因素的关系。 113例最初不可切除的CRLM患者中有35例（31.0%）发展为DLM，361处病变中有177处（49.0%）消失。术后6个月、6-12个月、12-24个月复发率分别为3.4%、16.8%、34.8%，24个月后无复发。单纯化疗组与化疗联合靶向治疗组DLM发生率比较差异有统计学意义（58.3% vs.37.1%，P < 0.001）。DLM<5 mm group and >的发生率在10 mm组（76.7% vs.30.4%，P < 0.001）、5-10 mm组（70.0% vs.30.4%，P <0.001）与>10 mm组（30.4%，P < 0.001）之间有显著差异。经单因素和多因素分析，年龄（P = 0.026，95%CI = 3.690）和治疗方案（P = 0.033，95%CI = 2.703）对DLM的无进展生存期（PFS）有显著影响。 年轻的患者，谁使用化疗单独达到治疗效果，可能有更好的生存优势时，病变没有进展后2年内出现DLMs。
The purpose of the current study was to analyze the influence of radiological “disappearing liver metastasis” (DLM) on the efficacy and prognosis of patients with colorectal liver metastases (CRLM) undergoing conversion therapy. Patients with CRLM by the multidisciplinary team (MDT) of the First Affiliated Hospital of Chongqing Medical University were retrospectively enrolled from January 2014 to January 2021. The relationship between the occurrence and recurrence of DLM and different clinical factors was analyzed. Thirty-five of the 113 patients (31.0%) with initially unresectable CRLM developed DLM, and of the 361 lesions, 177 disappeared (49.0%). Within 6 months, 6-12 months, and 12-24 months groups, the recurrence rate was 3.4%, 16.8%, and 34.8%, but there is no recurrence in after 24 months group. There was a statistical difference between chemotherapy alone and chemotherapy combined with the targeted therapy group on the occurrence of DLM (58.3% vs. 37.1%, P < 0.001). There were significant differences between <5 mm group and >10 mm group on occurrence of DLM（76.7% vs. 30.4%, P < 0.001) and between 5-10 mm group and >10 mm group also (70.0% vs. 30.4%, P < 0.001). Through univariate and multivariate analyses, it was concluded that age (P = 0.026, 95%CI = 3.690) and treatment regimens (P = 0.033, 95%CI = 2.703) had a significant influence on the progression-free survival (PFS) time of DLM. Younger patients, who use chemotherapy alone to achieve a therapeutic effect, might have better survival benefits when the lesions do not progress within 2 years after the appearance of DLMs.
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影响因子：
9
作者：
Goere, Diane;Gaujoux, Sebastien;Elias, Dominique
通讯作者：
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作者：
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通讯作者：
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作者：
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