Role of O-linked N-acetylglucosamine (O-GlcNAc) modification of proteins in diabetic cardiovascular complications.
Role of O-linked N-acetylglucosamine (O-GlcNAc) modification of proteins in diabetic cardiovascular complications.
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DOI：
10.1016/j.coph.2020.08.005
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发表时间：
2021-04
影响因子：
4
通讯作者：
中科院分区：
文献类型：
--
作者：
O-linked n -乙酰氨基葡萄糖（O-GlcNAc）对蛋白质丝氨酸和苏氨酸残基的翻译后修饰调节心血管系统中的多种细胞过程。UDP-GlcNAc是O-GlcNAc转移酶的底物，催化O-GlcNAc附着于蛋白质。O-GlcNAcase催化O-GlcNAc从蛋白质中去除。UDP-GlcNAc是己糖胺生物合成途径的最终产物，该途径主要由葡萄糖-6-磷酸-谷氨酰胺：果糖-6-磷酸氨基转移酶（GFAT）调节。GFAT催化6-磷酸果糖和谷氨酰胺生成6-磷酸葡萄糖胺。虽然O-GlcNAc对细胞活力至关重要，但O-GlcNAc水平的持续增加与许多慢性疾病的病因有关，并与包括心血管系统在内的各种器官的葡萄糖毒性和糖尿病并发症有关。本文综述了蛋白o - glcn酰化的调控，随后讨论了o - glcnac酰化循环失调导致糖尿病对心血管系统不良影响的潜在机制。
The post-translational modification of serine and threonine residues of proteins by O-linked N-acetylglucosamine (O-GlcNAc) regulates diverse cellular processes in the cardiovascular system. UDP-GlcNAc is a substrate for O-GlcNAc transferase, which catalyzes the attachment of O-GlcNAc to proteins. O-GlcNAcase catalyzes the removal of O-GlcNAc from proteins. UDP-GlcNAc is the end product of the hexosamine biosynthesis pathway, which is regulated primarily by glucose-6-phosphate-Glutamine:fructose-6-phosphate amidotransferase (GFAT). GFAT catalyzes the formation of glucosamine-6-phosphate from fructose-6-phosphate and glutamine. Whereas O-GlcNAc is essential for cell viability, sustained increases in O-GlcNAc levels have been implicated in the etiology of many chronic diseases and is associated with glucose toxicity and diabetic complications in various organs including the cardiovascular system. This review provides an overview of the regulation of protein O-GlcNAcylation followed by a discussion of potential mechanisms by which dysregulation in O-GlcNAc cycling contributes to the adverse effects of diabetes on the cardiovascular system.
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AMPK激活通过减少O-Glcnacylation来抵消心脏肥大。
影响因子：
16.6
作者：
Gélinas R;Mailleux F;Dontaine J;Bultot L;Demeulder B;Ginion A;Daskalopoulos EP;Esfahani H;Dubois-Deruy E;Lauzier B;Gauthier C;Olson AK;Bouchard B;Des Rosiers C;Viollet B;Sakamoto K;Balligand JL;Vanoverschelde JL;Beauloye C;Horman S;Bertrand L
通讯作者：
Bertrand L
影响因子：
20.1
作者：
Heath JM;Sun Y;Yuan K;Bradley WE;Litovsky S;Dell'Italia LJ;Chatham JC;Wu H;Chen Y
通讯作者：
Chen Y
DOI：
10.1042/bj20141018
发表时间：
2015-04-01
期刊：
The Biochemical journal
影响因子：
--
作者：
Dassanayaka S;Readnower RD;Salabei JK;Long BW;Aird AL;Zheng YT;Muthusamy S;Facundo HT;Hill BG;Jones SP
通讯作者：
Jones SP
影响因子：
3.9
作者：
Durand, Philippe;Golinelli-Pimpaneau, Beatrice;Badet-Denisot, Marie-Anae
通讯作者：
Badet-Denisot, Marie-Anae
影响因子：
5.3
作者：
Han, I;Kudlow, JE
通讯作者：
Kudlow, JE