Tissue-resident CD4(+) T helper cells assist the development of protective respiratory B and CD8(+) T cell memory responses.
Tissue-resident CD4(+) T helper cells assist the development of protective respiratory B and CD8(+) T cell memory responses.
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DOI：
10.1126/sciimmunol.abb6852
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发表时间：
2021-01-08
影响因子：
24.8
通讯作者：
Sun J
中科院分区：
文献类型：
--
作者：
Son YM;Cheon IS;Wu Y;Li C;Wang Z;Gao X;Chen Y;Takahashi Y;Fu YX;Dent AL;Kaplan MH;Taylor JJ;Cui W;Sun J
Much remains unknown about the roles of CD4+ T helper cells in shaping localized memory B cell and CD8+ T cell immunity in the mucosal tissues. Here, we report that lung T helper cells provide local assistance for the optimal development of tissue-resident memory B and CD8+ T cells after the resolution of primary influenza virus infection. We have identified a population of T cells in the lung that exhibit characteristics of both follicular T helper and TRM cells, and we have termed these cells as resident helper T (TRH) cells. Optimal TRH cell formation was dependent on transcription factors involved in T follicular helper and resident memory T cell development including BCL6 and Bhlhe40. We show that TRH cells deliver local help to CD8+ T cells through IL-21–dependent mechanisms. Our data have uncovered the presence of a tissue-resident helper T cell population in the lung that plays a critical role in promoting the development of protective B cell and CD8+ T cell responses.
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影响因子：
64.8
作者：
Iijima N;Iwasaki A
通讯作者：
Iwasaki A
影响因子：
24.8
作者：
Kuenzli, Marco;Schreiner, David;King, Carolyn G.
通讯作者：
King, Carolyn G.
DOI：
10.1084/jem.20101850
发表时间：
2011-01-17
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Hufford MM;Kim TS;Sun J;Braciale TJ
通讯作者：
Braciale TJ
影响因子：
7.8
作者：
Clemens EB;van de Sandt C;Wong SS;Wakim LM;Valkenburg SA
通讯作者：
Valkenburg SA
影响因子：
16.6
作者：
Vu Van D;Beier KC;Pietzke LJ;Al Baz MS;Feist RK;Gurka S;Hamelmann E;Kroczek RA;Hutloff A
通讯作者：
Hutloff A