Comparison of Associations of DXA and CT Visceral Adipose Tissue Measures With Insulin Resistance, Lipid Levels, and Inflammatory Markers.
Comparison of Associations of DXA and CT Visceral Adipose Tissue Measures With Insulin Resistance, Lipid Levels, and Inflammatory Markers.
复制标题
DOI：
10.1016/j.jocd.2017.01.004
复制
发表时间：
2017-04
期刊：
影响因子：
--
通讯作者：
Osteoporotic Fractures in Men (MrOS) Study Research Group
中科院分区：
文献类型：
--
作者：
Schousboe JT;Langsetmo L;Schwartz AV;Taylor BC;Vo TN;Kats AM;Barrett-Connor E;Orwoll ES;Marshall LM;Miljkovic I;Lane NE;Ensrud KE;Osteoporotic Fractures in Men (MrOS) Study Research Group
通过计算机断层扫描（CT）测量的内脏脂肪组织（VAT）与胰岛素抵抗、脂质和血清炎症标志物相关。我们的目的是比较内脏脂肪组织（VAT）与胰岛素抵抗，血脂和炎症血清标志物的双能X线吸收测定法（DXA-VAT）和计算机断层扫描（CT-VAT）测量的相关性的强度。对于1,117名65岁及以上的男性参加了男性骨质疏松性骨折研究（MrOS），DXA-VAT和CT-VAT与胰岛素抵抗（homa 2 ir）、C反应蛋白（CRP）和HDL胆固醇的稳态模型评估的横截面关联使用回归模型进行估计，并使用豪斯曼检验进行比较。校正年龄和体重指数（BMI）后，DXA-VAT与homa 2 ir中度相关（效应量0.38，95% C.I. 0.28至0.47），并与HDL胆固醇中度相关（DXA效应量-0.29，95% C.I. -0.38到-0.21）。这些相关性显著大于CT-VAT与homa 2 ir的相关性（0.30，95% C.I. 0.24至0.37;效应量差异p值0.03）和CT-VAT与HDL胆固醇（-0.22，95% C.I. -0.29至-0.15;差异p值0.005）。调整年龄和BMI后，DXA-VAT和CT-VAT均与CRP无关（DXA-VAT效应量0.14，95%CI−0.04至0.32; CT-VAT效应量0.08，95% C.I. -0.08至0.25;差异的p值为0.35）。DXA-VAT与胰岛素抵抗和HDL胆固醇的相关性与老年男性中的CT-VAT相似或更大，证实了DXA-VAT的同时有效性。有必要研究DXA测量VAT对心血管疾病事件的预测效果。
Visceral adipose tissue (VAT) measured by computed tomography (CT) is related to insulin resistance, lipids, and serum inflammatory markers. Our objective was to compare the strength of the associations of visceral adipose tissue (VAT) measured with dual energy x-ray absorptiometry (DXA-VAT) and computed tomography (CT-VAT) with insulin resistance, serum lipids, and serum markers of inflammation. For 1,117 men age 65 and older enrolled in the Study of Osteoporotic Fractures in Men (MrOS), the cross-sectional associations of DXA-VAT and CT-VAT with Homeostasis Model Assessment of insulin resistance (homa2ir), C-reactive protein (CRP), and HDL cholesterol were estimated with regression models, and compared using a Hausmann test. Adjusted for age and body mass index (BMI), DXA-VAT was moderately associated with homa2ir (effect size 0.38, 95% C.I. 0.28 to 0.47) and modestly associated with HDL cholesterol (DXA effect size −0.29, 95% C.I. −0.38 to −0.21). These associations were significantly greater than for CT-VAT with homa2ir (0.30, 95% C.I. 0.24 to 0.37; p-value for effect size difference 0.03) and CT-VAT with HDL cholesterol (-0.22, 95% C.I. −0.29 to −0.15; p-value for difference 0.005). Neither DXA-VAT nor CT-VAT were associated with CRP after adjustment for age and BMI (DXA-VAT effect size 0.14, 95% C.I. −0.04 to 0.32; CT-VAT effect size 0.08, 95% C.I. −0.08 to 0.25; p-value for difference 0.35). DXA-VAT has similar or greater associations with insulin resistance, and HDL cholesterol as does CT-VAT in older men, confirming the concurrent validity of DXA-VAT. Investigations of how well DXA measurements of VAT predict incident cardiovascular disease events are warranted.
登录
查看更多内容
影响因子：
16.2
作者：
Hill NR;Levy JC;Matthews DR
通讯作者：
Matthews DR
影响因子：
4.7
作者：
Bi X;Seabolt L;Shibao C;Buchowski M;Kang H;Keil CD;Tyree R;Silver HJ
通讯作者：
Silver HJ
影响因子：
6.2
作者：
Marshall, Lynn M.;Lang, Thomas F.;Orwoll, Eric S.
通讯作者：
Orwoll, Eric S.
影响因子：
6.9
作者：
Miljkovic, Iva;Cauley, Jane A.;Wang, Patty Y.;Holton, Kathleen F.;Lee, Christine G.;Sheu, Yahtyng;Barrett-Connor, Elizabeth;Hoffman, Andrew R.;Lewis, Cora B.;Orwoll, Eric S.;Stefanick, Marcia L.;Strotmeyer, Elsa S.;Marshall, Lynn M.
通讯作者：
Marshall, Lynn M.
影响因子：
5.3
作者：
Imai, Atsuko;Komatsu, Sei;Kodama, Kazuhisa
通讯作者：
Kodama, Kazuhisa