Abdominal myosteatosis is independently associated with hyperinsulinemia and insulin resistance among older men without diabetes.
Abdominal myosteatosis is independently associated with hyperinsulinemia and insulin resistance among older men without diabetes.
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DOI：
10.1002/oby.20346
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发表时间：
2013-10
期刊：
影响因子：
6.9
通讯作者：
Marshall, Lynn M.
中科院分区：
文献类型：
--
作者：
Miljkovic, Iva;Cauley, Jane A.;Wang, Patty Y.;Holton, Kathleen F.;Lee, Christine G.;Sheu, Yahtyng;Barrett-Connor, Elizabeth;Hoffman, Andrew R.;Lewis, Cora B.;Orwoll, Eric S.;Stefanick, Marcia L.;Strotmeyer, Elsa S.;Marshall, Lynn M.
骨骼肌脂肪组织（AT）浸润（骨骼肌骨化症）随着年龄的增长而增加，并可能导致2型糖尿病（T2DM）的发展。目前尚不清楚肌肥大症是否与葡萄糖和胰岛素稳态相关，而不依赖于全脂性和中枢性肥胖。我们评估了393名65岁以上非糖尿病白人男性腹部骨骼肌（总肌、棘旁肌和腰肌）肌间AT （IMAT）与空腹血糖、胰岛素和胰岛素抵抗稳态模型评估（HOMA-IR）之间的关系。通过L4-L5椎间隙定量计算机断层扫描测量腹部IMAT、内脏（VAT）和皮下（SAT） AT （cm3）。在年龄、研究地点、身高和肌肉体积校正回归分析中，腹部和腰肌总IMAT（但不包括棘旁肌）与葡萄糖、胰岛素和HOMA-IR呈正相关（均P < 0.003）。在单独的模型中，在进一步调整生活方式因素以及DXA、总体脂、VAT或SAT后，腹部和腰肌总IMAT与胰岛素和HOMA-IR之间的相关性仍然显著（均P <0.009）。我们的研究表明，在老年高加索男性中，腹部肌骨化症与高胰岛素血症和胰岛素抵抗之间存在先前未报道的独立关联。这些关联可能是特定的腹肌库，说明单独研究特定肌肉群的潜在重要性。
Skeletal muscle adipose tissue (AT) infiltration (myosteatosis) increases with aging and may contribute to the development of type 2 diabetes mellitus (T2DM). It remains unclear if myosteatosis is associated to glucose and insulin homeostasis independent of total and central adiposity. We evaluated the association between intermuscular AT (IMAT) in the abdominal skeletal muscles (total, paraspinal and psoas) and fasting serum glucose, insulin, and homeostasis model assessment of insulin resistance (HOMA-IR) in 393 non-diabetic Caucasian men aged 65+. Abdominal IMAT, visceral (VAT) and subcutaneous (SAT) AT (cm3) were measured by quantitative computed tomography at the L4-L5 intervertebral space. In age, study site, height and muscle volume adjusted regression analyses, total abdominal and psoas (but not paraspinal) IMAT were positively associated with glucose, insulin and HOMA-IR (all P < 0.003). The associations between total abdominal and psoas IMAT and insulin and HOMA-IR remained significant after further adjusting for lifestyle factors, as well as DXA total body fat, VAT or SAT in separate models (all P <0.009). Our study indicates a previously unreported, independent association between abdominal myosteatosis and hyperinsulinemia and insulin resistance among older Caucasian men. These associations may be specific for particular abdominal muscle depots, illustrating the potential importance of separately studying specific muscle groups.
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影响因子：
4.1
作者：
KERN, M;WELLS, JA;DOHM, GL
通讯作者：
DOHM, GL
影响因子：
7.7
作者：
Kovalik, Jean-Paul;Slentz, Dorothy;Muoio, Deborah M.
通讯作者：
Muoio, Deborah M.
影响因子：
6.2
作者：
Marshall, Lynn M.;Lang, Thomas F.;Orwoll, Eric S.
通讯作者：
Orwoll, Eric S.
影响因子：
5.8
作者：
Goodpaster, BH;He, J;Kelley, DE
通讯作者：
Kelley, DE
影响因子：
2.2
作者：
Orwoll, E;Blank, JB;Stone, K
通讯作者：
Stone, K