Is there a role for high dose chemotherapy and blood stem cell rescue in childhood hepatoblastoma presenting with lung metastases? A case report and literature review.
Is there a role for high dose chemotherapy and blood stem cell rescue in childhood hepatoblastoma presenting with lung metastases? A case report and literature review.
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DOI：
10.1186/1824-7288-39-65
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发表时间：
2013-10-22
影响因子：
3.6
通讯作者：
Da Dalt L
中科院分区：
文献类型：
--
作者：
Provenzi M;Saettini F;Conter V;Giraldi E;Foglia C;Cavalleri L;Colledan M;D'Antiga L;Perilongo G;Da Dalt L
我们报告使用高剂量化疗与外周血干细胞救援作为巩固治疗的3岁儿童受转移性肝母细胞瘤，谁实现了完全肺反应后，只有常规治疗。患者目前在高剂量化疗和造血干细胞挽救后存活27个月，无疾病证据。高剂量化疗联合造血干细胞挽救在巩固转移性肝母细胞瘤肺部疾病完全清除方面的作用仍存在争议;文献中的可用数据和我们的经验似乎表明，在高危患者的临床环境中，应进一步考虑这种治疗选择。
We report the use of high dose chemotherapy with peripheral blood stem cell rescue as a consolidation treatment for a 3-year-old child affected by metastatic hepatoblastoma, who achieved complete lung response only after conventional treatment. The patient is presently alive 27 months after high dose chemotherapy with blood stem cell rescue with no evidence of disease. The role of high dose chemotherapy with blood stem cell rescue to consolidate the complete clearing of lung disease in metastatic hepatoblastoma remains controversial; the data available in the literature and our experience seems to suggest to keep this treatment option open to further consideration in the clinical setting of high-risk patients.
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影响因子：
8.4
作者：
Maibach, Rudolf;Roebuck, Derek;Perilongo, Giorgio
通讯作者：
Perilongo, Giorgio
影响因子：
6.2
作者：
Fuchs, J;Rydzynski, J;Mildenberger, H
通讯作者：
Mildenberger, H
影响因子：
2.2
作者：
Yoshinari, M;Imaizumi, M;Iinuma, K
通讯作者：
Iinuma, K
影响因子：
45.3
作者：
Katzenstein, HM;London, WB;Bowman, LC
通讯作者：
Bowman, LC
影响因子：
45.3
作者：
Zsiros, Jozsef;Maibach, Rudolf;Perilongo, Giorgio
通讯作者：
Perilongo, Giorgio