Correlations between APOE4 allele and regional amyloid and tau burdens in cognitively normal older individuals.
Correlations between APOE4 allele and regional amyloid and tau burdens in cognitively normal older individuals.
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DOI：
10.1038/s41598-022-18325-2
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发表时间：
2022-08-22
影响因子：
4.6
通讯作者：
Sepulcre, Jorge
中科院分区：
文献类型：
--
作者：
Hong, Yun Jeong;Kim, Chan-Mi;Lee, Jae Hong;Sepulcre, Jorge
在认知功能正常的老年人中，载脂蛋白<$4（APOE 4）状态与局部淀粉样蛋白、tau蛋白和皮质厚度之间的相关性尚未完全了解。我们的横断面研究旨在根据APOE 4携带状态比较区域淀粉样蛋白/tau蛋白负荷和皮质厚度，并评估APOE 4和阿尔茨海默病（AD）相关生物标志物负荷之间的相关性。我们分析了来自阿尔茨海默病神经影像学倡议（ADNI）队列的185名认知正常的参与者。年龄在55-90岁、认知功能正常的受试者被分为淀粉样蛋白A阳性（AAPOE+）APOE 4携带者（第1组，n = 27）、AAPOE + APOE 4非携带者（第2组，n = 29）和AAPOE-正常对照（第0组，n = 129）。我们比较了三组之间的淀粉样蛋白沉积、tau蛋白沉积和皮质厚度，并评估了APOE 4存在与根据年龄和性别调整的成像生物标志物之间的相关性。第二组的参与者年龄大于其他组。区域淀粉样蛋白/tau蛋白标准化摄取值比值（SUVR）在组1和组2之间没有差异，但在调整年龄差异后，大多数区域的淀粉样蛋白/tau蛋白SUVR在数值上较高。APOE 4等位基因在校正年龄和性别后与额颞顶叶皮质区淀粉样蛋白负荷增加具有强相关性，但与区域tau负荷具有较弱和混合相关性，与皮质厚度无显著相关性。我们发现，在认知正常的老年人中，APOE 4等位基因的存在与淀粉样蛋白沉积的相关性可能比与其他AD相关生物标志物（如tau蛋白或皮质厚度）的相关性更高。
The correlations between apolipoprotein epsilon 4 (APOE4) status and regional amyloid, tau, and cortical thickness in cognitively normal elderly are not fully understood. Our cross-sectional study aimed to compare regional amyloid/tau burden, and cortical thickness according to APOE4 carrier status and assess correlations between APOE4 and Alzheimer’s disease (AD)-related biomarker burdens. We analyzed 185 cognitively normal participants from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) cohort. Participants aged 55–90 with normal cognitive function were divided into amyloid ß-positive (Aß+) APOE4 carriers (group 1, n = 27), Aß+ APOE4 non-carriers (group 2, n = 29), and Aß− normal controls (group 0, n = 129). We compared amyloid depositions, tau depositions, and cortical thickness among the three groups and assessed correlations between APOE4 existence and imaging biomarkers adjusted for age and sex. The participants in group 2 were older than those in the other groups. The regional amyloid/tau standardized uptake value ratios (SUVRs) did not differ between groups 1 and 2, but the amyloid/tau SUVRs in most regions were numerically higher after adjusting for age difference. APOE4 allele had robust correlations with increased amyloid burden in the fronto-temporo-parietal cortical areas after adjustment for age and sex, but it had weaker and mixed correlations with the regional tau burden and did not have significant correlation with cortical thickness. We identified that the presence of APOE4 allele might be more highly associated with amyloid deposition than with other AD-related biomarkers such as tau or cortical thickness in cognitively normal elderly.
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影响因子：
29
作者：
Therriault, Joseph;Benedet, Andrea L.;Rosa-Neto, Pedro
通讯作者：
Rosa-Neto, Pedro
影响因子：
9.9
作者：
Cummings, JL
通讯作者：
Cummings, JL
载脂蛋白Eε4等位基因对纵向认知轨迹的影响是性别和年龄依赖性的。
DOI：
10.1016/j.jalz.2019.07.011
发表时间：
2019-12
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
--
作者：
Williams OA;An Y;Armstrong NM;Shafer AT;Helphrey J;Kitner-Triolo M;Ferrucci L;Resnick SM
通讯作者：
Resnick SM
影响因子：
120.7
作者：
Jansen, Willemijn J.;Ossenkoppele, Rik;Knol, Dirk L.;Tijms, Betty M.;Scheltens, Philip;Verhey, Frans R. J.;Visser, Pieter Jelle
通讯作者：
Visser, Pieter Jelle
影响因子：
64.8
作者：
Shi Y;Yamada K;Liddelow SA;Smith ST;Zhao L;Luo W;Tsai RM;Spina S;Grinberg LT;Rojas JC;Gallardo G;Wang K;Roh J;Robinson G;Finn MB;Jiang H;Sullivan PM;Baufeld C;Wood MW;Sutphen C;McCue L;Xiong C;Del-Aguila JL;Morris JC;Cruchaga C;Alzheimer’s Disease Neuroimaging Initiative;Fagan AM;Miller BL;Boxer AL;Seeley WW;Butovsky O;Barres BA;Paul SM;Holtzman DM
通讯作者：
Holtzman DM