Apolipoprotein E ε4 allele effects on longitudinal cognitive trajectories are sex and age dependent.
Apolipoprotein E ε4 allele effects on longitudinal cognitive trajectories are sex and age dependent.
复制标题
载脂蛋白Eε4等位基因对纵向认知轨迹的影响是性别和年龄依赖性的。
DOI：
10.1016/j.jalz.2019.07.011
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发表时间：
2019-12
期刊：
影响因子：
--
通讯作者：
Resnick SM
中科院分区：
文献类型：
--
作者：
Williams OA;An Y;Armstrong NM;Shafer AT;Helphrey J;Kitner-Triolo M;Ferrucci L;Resnick SM
关于载脂蛋白E-ε4对男性和女性认知下降的影响是否相似，以及载脂蛋白-ε4和年龄如何相互作用影响不同认知领域的下降，仍然存在疑问。在性别分层分析中，研究了认知正常的老年人(631名男性，561名女性，基线年龄范围：50-93,6733次评估)中载脂蛋白E-ε4状态和纵向认知轨迹之间的年龄相关性。在发现年龄依赖关系的地方，估计APOE基因型轨迹的分歧年龄。在男性中，ApoE-ε4对记忆和执行功能的纵向衰退有显著的年龄依赖性影响，分别从基线年龄和68岁开始检测到。在女性中，ApoE-ε4对基线年龄为66岁的可检测到的注意力纵向下降具有显著的年龄相关性影响。在语言、视觉空间能力和加工速度方面没有发现显著的APOE-ε4效应。结果强调了在评估载脂蛋白E-ε4相关的认知衰退易感性时考虑性别和年龄的重要性。
Questions remain about whether APOE-ε4 effects on cognitive decline are similar in men and women and how APOE-ε4 and age interact to influence decline in different cognitive domains. In sex stratified analyses, age-dependent associations between APOE-ε4 status and longitudinal cognitive trajectories were examined in cognitively normal older adults (631 men, 561 women, baseline age range: 50–93, 6733 assessments). Where age-dependent relationships were found, age of divergence in trajectories for APOE genotypes was estimated. In men, APOE-ε4 had significant age-dependent effects on longitudinal decline in memory and executive function detectible from baseline age of 64 and 68, respectively. In women, APOE-ε4 had a significant age-dependent effect on longitudinal decline in attention detectible at baseline age of 66. No significant APOE-ε4 effects were found for language, visual-spatial ability or processing speed. Results highlight the importance of considering sex and age when assessing APOE-ε4 associated vulnerability to cognitive decline.
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影响因子：
2.6
作者：
Bunce, David;Anstey, Kaarin J.;Easteal, Simon
通讯作者：
Easteal, Simon
DOI：
10.1016/j.jalz.2018.04.010
发表时间：
2018-09
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
--
作者：
Buckley RF;Mormino EC;Amariglio RE;Properzi MJ;Rabin JS;Lim YY;Papp KV;Jacobs HIL;Burnham S;Hanseeuw BJ;Doré V;Dobson A;Masters CL;Waller M;Rowe CC;Maruff P;Donohue MC;Rentz DM;Kirn D;Hedden T;Chhatwal J;Schultz AP;Johnson KA;Villemagne VL;Sperling RA;Alzheimer's Disease Neuroimaging Initiative;Australian Imaging, Biomarker and Lifestyle study of ageing;Harvard Aging Brain Study
通讯作者：
Harvard Aging Brain Study
影响因子：
4.2
作者：
Armstrong, Nicole M.;Huang, Chiung-Wei;Resnick, Susan M.
通讯作者：
Resnick, Susan M.
影响因子：
4.2
作者：
Beydoun MA;Boueiz A;Abougergi MS;Kitner-Triolo MH;Beydoun HA;Resnick SM;O'Brien R;Zonderman AB
通讯作者：
Zonderman AB
影响因子：
4.2
作者：
Jochemsen, Hadassa M.;Muller, Majon;Geerlings, Mirjam I.
通讯作者：
Geerlings, Mirjam I.