Repeated confocal imaging of individual dendritic spines in the living hippocampal slice: evidence for changes in length and orientation associated with chemically induced LTP
Repeated confocal imaging of individual dendritic spines in the living hippocampal slice: evidence for changes in length and orientation associated with chemically induced LTP
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活体海马切片中单个树突棘的重复共聚焦成像:与化学诱导的 LTP 相关的长度和方向变化的证据
DOI:
10.1523/jneurosci.15-08-05560.1995
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发表时间:
1995
期刊:
影响因子:
--
通讯作者:
Monte Carlo Sim
中科院分区:
文献类型:
--
作者:
T. Hosokawa;D. Rusakov;T. V. P. Bliss;Alan Fine;Monte Carlo Sim
Using confocal microscopy in conjunction with microdrop application of Dil, we have imaged and measured individual dendritic spines of living hippocampal CA1 pyramidal neurons in acute brain slices, before and approximately 3 hr after induction of long-term potentiation by chemical means. Statistical analysis of changes in the length of individual spines, and comparison with results of Monte Carlo simulations, suggests that two forms of structural change occur in chemically induced long-term potentiation: growth of a subpopulation of small spines, and angular displacement of spines. These changes could provide a structural basis for the expression of long-term potentiation.
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影响因子:
3.7
作者:
Nemoto TK;Ohara Nemoto Y
通讯作者:
Ohara Nemoto Y
DOI:
10.1097/01.wnr.0000078380.40088.99
发表时间:
2003
期刊:
Neuroreport.
影响因子:
--
作者:
McCarthy,JBrian;Milner,TeresaA
通讯作者:
Milner,TeresaA
DOI:
10.1073/pnas.81.11.3572
发表时间:
1984
影响因子:
11.1
作者:
Siman,R;Baudry,M;Lynch,G
通讯作者:
Lynch,G
影响因子:
56.9
作者:
SILVA, AJ;STEVENS, CF;WANG, YY
通讯作者:
WANG, YY