Tissue-specific expression of three distinct types of rabbit protein kinase C
Tissue-specific expression of three distinct types of rabbit protein kinase C
复制标题
三种不同类型兔蛋白激酶 C 的组织特异性表达
作者：
S. Ohno;H. Kawasaki;S. Imajoh;Koichi Suzuki;M. Inagaki;H. Yokokura;T. Sakoh;H. Hidaka
我们研究了蛋白激酶C的结构，试图了解蛋白激酶C激活与细胞反应1-3之间的分子事件。编码三种不同类型蛋白激酶C的兔互补基因克隆已被鉴定和测序，命名为α，β和γ。α，β和γ的推导氨基酸序列(分别为673、671和672个氨基酸)密切相关。α和β具有相同的621个氨基酸残基的电视末端序列，它们的信使RNA来自同一个基因。α，β和γ的C末端部分是蛋白激酶结构域，与其他蛋白激酶高度同源。α，β和γ的mRNAs在不同组织中表达，具有明显不同的组织特异性。γ基因在各种组织中普遍存在，而α和β基因在大脑中占主导地位。
We examined the structure of protein kinase C in an attempt to understand the molecular events connecting protein kinase C activation with the cellular response 1–3. Rabbit complementary DNA clones coding for three distinct types of protein kinase C, named α, β and γ, have been identified and sequenced. The deduced amino acid sequence for α, β and γ (673, 671 and 672 amino acids, respectively) are closely related. Kinases α and β share an identical TV-terminal sequence of 621 amino acid residues and their messenger RNAs arise from a single gene. The C-terminal halves of α, β and γ are protein kinase domains and are highly homologous to other protein kinases. The mRNAs for α, β and γ are expressed in various tissues with strikingly different tissue specificities. The one for γ is found ubiquitously among various tissues, while those for α and β predominate in the brain.
两种禽肉瘤病毒转化蛋白磷酸转移酶活性催化结构域的分析。
DOI：
--
发表时间：
1984
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Brugge,JS;Darrow,D
通讯作者：
Darrow,D
牛 II 型腺苷环状 3,5-磷酸依赖性蛋白激酶催化亚基的氨基酸序列。
影响因子：
2.9
作者：
Shoji,S;Ericsson,LH;Walsh,KA;Fischer,EH;Titani,K
通讯作者：
Titani,K
影响因子：
56.9
作者：
GREENE, GL;GILNA, P;SHINE, J
通讯作者：
SHINE, J