Development of a research agenda for evaluation of interventional therapies for chronic cerebrospinal venous insufficiency: proceedings from a multidisciplinary research consensus panel.
Development of a research agenda for evaluation of interventional therapies for chronic cerebrospinal venous insufficiency: proceedings from a multidisciplinary research consensus panel.
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制定评估慢性脑脊髓静脉功能不全介入治疗的研究议程：多学科研究共识小组的程序。
DOI：
10.1016/j.jvir.2011.03.007
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Sauder,Heidi
中科院分区：
文献类型：
--
作者：
Siskin,GaryP;Haskal,ZivJ;McLennan,Gordon;Dake,MichaelD;Haacke,EMark;McDonald,Sandy;Royal3rd,Walter;Vedantham,Suresh;Hubbard,David;Sclafani,SalvatoreJ;Andrews,RTorrance;Sauder,Heidi
多发性硬化症(MS)是中枢神经系统(CNS)的一种慢性炎症性疾病，会导致髓鞘受损，大脑、脊髓和视神经中的轴突也会受到损害。目前，我们对多发性硬化症的病理生理学的理解主要集中在免疫介导的对中枢神经系统髓鞘抗原的攻击(1，2)。多发性硬化症引起的症状多种多样，从轻微到非常虚弱不等。当患者出现典型的临床表现时，核磁共振(MR)成像往往能显示出特征性的白质病变，这证实了MS(2，3)的诊断。对多发性硬化症的不同治疗策略一直是人们关注的重点，通常关注的是试图使免疫系统的一个组成部分失效或防止疾病进行性形式出现的神经退化的疾病修饰药物。慢性脑脊髓静脉功能不全(CCSVI)是最初提出的解释多发性硬化症的发病机制和与这种疾病相关的症状的新理论的一部分。这一理论是由Paolo Zamboni提出的，其基础是观察到炎性病变沿脑静脉的解剖分布(5-7)。提示颅外静脉阻塞干扰了中枢静脉回流，参与了MS(8，9)的发生发展。CCSVI是否真的是多发性硬化症的前兆，或者是一个独立的临床实体，对一些经典的多发性硬化症症状负有责任，目前尚不清楚。然而，Zamboni等人(10)描述了多发性硬化症和静脉异常引流的相关性，以及他们用静脉血管成形术治疗这种情况的临床成功。这些报道引起了患者和医生对这种疗法在多发性硬化症中的作用的极大兴趣。
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) that results in damage to myelin and, to a lesser extent, axons in the brain, spinal cord, and optic nerves. Presently, our understanding of the pathophysiology of MS centers on an immune-mediated attack against CNS myelin antigens (1, 2). The symptoms caused by MS are variable and can range from mild to quite debilitating. When a patient presents with the typical clinical manifestations, characteristic white matter lesions are often visualized with magnetic resonance (MR) imaging, which confirms the diagnosis of MS (2, 3). Significant research has been focused on different treatment strategies for MS, with attention often paid to disease-modifying drugs that seek to disable a component of the immune system or to prevent the neurodegeneration seen in progressive forms of the disease (4).Chronic cerebrospinal venous insufficiency (CCSVI) is part of a new theory that was initially put forth to explain the pathogenesis of MS and the symptoms associated with this disease. This theory, put forth by Paolo Zamboni, has its basis in the observed anatomic distribution of inflammatory lesions along cerebral veins (5–7). It proposes that extracranial venous obstruction interferes with the venous drainage from the CNS, contributing to the development and progression of MS (8, 9). Whether CCSVI is truly a precursor to MS or an independent clinical entity responsible for some of the symptoms classically attributed to MS is not yet known. However, Zamboni et al (10) described a correlation between MS and abnormal venous drainage, as well as their clinical success in treating this condition with venous angioplasty. These reports have led to significant interest among patients and physicians about the role of this treatment in MS.
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大想法：静脉疾病中的铁依赖性炎症与多发性硬化症中的相似之处
影响因子：
17.3
作者：
P. Zamboni
通讯作者：
P. Zamboni
磁共振成像与多发性硬化症的神经心理损伤相关。
DOI：
10.1176/jnp.4.2.152
发表时间：
1992
期刊：
The Journal of neuropsychiatry and clinical neurosciences
影响因子：
--
作者：
S. Huber;R. Bornstein;K. Rammohan;J. A. Christy;D. Chakeres;R. McGhee
通讯作者：
R. McGhee
DOI：
10.1097/nrl.0b013e318157f791
发表时间：
2008
期刊：
The Neurologist
影响因子：
--
作者：
R. Agid;I. Shelef;J. Scott;R. Farb
通讯作者：
R. Farb
DOI：
10.1001/jama.1937.02780180001001
发表时间：
1937-01-01
影响因子：
--
作者：
Putnam, TJ
通讯作者：
Putnam, TJ
影响因子：
1.7
作者：
Ludyga, T.;Kazibudzki, M.;Tochowicz, M.
通讯作者：
Tochowicz, M.