Magnetic resonance imaging correlates of neuropsychological impairment in multiple sclerosis.

Magnetic resonance imaging correlates of neuropsychological impairment in multiple sclerosis.
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磁共振成像与多发性硬化症的神经心理损伤相关。

DOI:
10.1176/jnp.4.2.152
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发表时间:
1992
期刊:
The Journal of neuropsychiatry and clinical neurosciences
影响因子:
--
通讯作者:
R. McGhee
R. McGhee
中科院分区:
--
文献类型:
--
作者:
S. Huber;R. Bornstein;K. Rammohan;J. A. Christy;D. Chakeres;R. McGhee

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作者研究了多发性硬化症 (MS) 中的特定神经心理学异常是否与 MRI 检测到的局灶性病变区域相关。病变面积,无论分布如何,都与绝大多数神经心理学程序的表现相关。在任何 MRI 测量中,正常/轻度和中度总体认知障碍组之间均未出现显着差异。然而,与其他两组相比,严重认知障碍患者的病变面积更大,无论位置如何,并且胼胝体萎缩明显。这些结果表明,胼胝体的严重萎缩反映了整体疾病,并为多发性硬化症严重认知障碍提供了相对局灶性的形态学标志。
The authors examined whether specific neuropsychological abnormalities in multiple sclerosis (MS) are associated with focal lesion areas detected by MRI. Lesion area, regardless of distribution, correlated with performance on the vast majority of neuropsychological procedures. No significant difference appeared between groups with normal/mild and moderate overall cognitive impairment on any of the MRI measures. However, patients with severe cognitive impairment had greater lesion area, regardless of location, and had significant atrophy of the corpus callosum compared with the other two groups. These results suggest that severe atrophy of the corpus callosum reflects global disease and provides a relatively focal morphological marker of severe cognitive impairment in MS.
DOI: 10.1001/archneur.1989.00520440114028
发表时间: 1989
影响因子: --
作者:
Rao,SM;Bernardin,L;Leo,GJ;Ellington,L;Ryan,SB;Burg,LS
通讯作者: Burg,LS
多发性硬化症的磁共振成像和临床关系。
DOI: 10.1016/s0025-6196(12)62439-2
发表时间: 1987
影响因子: 8.9
作者:
Stewart,JM;Houser,OW;BakerJr,HL;O'Brien,PC;Rodriguez,M
通讯作者: Rodriguez,M
多发性硬化症的磁共振成像:32 例结果。
DOI: --
发表时间: 1985
期刊: AJNR. American journal of neuroradiology
影响因子: --
作者:
Jackson,JA;Leake,DR;Schneiders,NJ;Rolak,LA;Kelley,GR;Ford,JJ;Appel,SH;Bryan,RN
通讯作者: Bryan,RN