Cells of the synovium in rheumatoid arthritis. Chondrocytes.
Cells of the synovium in rheumatoid arthritis. Chondrocytes.
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DOI：
10.1186/ar2292
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发表时间：
2007
影响因子：
4.9
通讯作者：
Goldring MB
中科院分区：
文献类型：
--
作者：
Otero M;Goldring MB
类风湿性关节炎（RA）是一组异质性疾病中的炎性关节疾病，其共同特征是关节软骨和骨的细胞外基质破坏。导致局部关节病理的免疫调节的潜在紊乱导致滑液和滑膜中释放炎性介质，其直接和间接影响软骨稳态。分析体液中关节软骨基质成分的分解产物和定量成像技术已被用于评估炎症性关节疾病对关节结构局部重塑的影响。软骨细胞本身在人类类风湿关节软骨破坏中的作用一直难以解决，但已从体外研究和动物模型中推断出来。这篇综述涵盖了目前的知识，具体的细胞和生化机制，占在RA的软骨基质的完整性的破坏。
Rheumatoid arthritis (RA) is one of the inflammatory joint diseases in a heterogeneous group of disorders that share features of destruction of the extracellular matrices of articular cartilage and bone. The underlying disturbance in immune regulation that is responsible for the localized joint pathology results in the release of inflammatory mediators in the synovial fluid and synovium that directly and indirectly influence cartilage homeostasis. Analysis of the breakdown products of the matrix components of joint cartilage in body fluids and quantitative imaging techniques have been used to assess the effects of the inflammatory joint disease on the local remodeling of joint structures. The role of the chondrocyte itself in cartilage destruction in the human rheumatoid joint has been difficult to address but has been inferred from studies in vitro and in animal models. This review covers current knowledge about the specific cellular and biochemical mechanisms that account for the disruption of the integrity of the cartilage matrix in RA.
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DOI：
10.1097/01.blo.0000143805.64755.4f
发表时间：
2004-10-01
影响因子：
4.2
作者：
Borzì, RM;Mazzetti, I;Facchini, A
通讯作者：
Facchini, A
DOI：
10.1016/j.bbrc.2005.11.016
发表时间：
2006-01-06
影响因子：
3.1
作者：
Chowdhury, TT;Bader, DL;Lee, DA
通讯作者：
Lee, DA
影响因子：
82.9
作者：
Diarra, Danielle;Stolina, Marina;Schett, Georg
通讯作者：
Schett, Georg
影响因子：
--
作者：
Aigner, Thomas;Fundel, Katrin;Bartnik, Eckart
通讯作者：
Bartnik, Eckart
影响因子：
6.1
作者：
Aida, Yukiko;Maeno, Masao;Makimura, Masaharu
通讯作者：
Makimura, Masaharu