Improving Blood Flow Simulations by Incorporating Measured Subject-Specific Wall Motion
Improving Blood Flow Simulations by Incorporating Measured Subject-Specific Wall Motion
复制标题
通过结合测量的特定对象的壁运动来改进血流模拟
DOI：
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复制
发表时间：
2014
期刊：
影响因子：
--
通讯作者：
T. Ebbers
中科院分区：
文献类型：
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作者：
Jonas Lantz;P. Dyverfeldt;T. Ebbers
血液流动的生理相关模拟需要允许壁变形的模型。通常使用流体-结构相互作用（FSI）方法;然而，该方法依赖于几个假设和难以或不可能在体内测量的患者特定材料参数。为了规避FSI模型中固有的假设，使用MRI测量主动脉壁运动并直接在数值求解器中规定。以这种方式不仅是占血管的位移，而且还与跳动的心脏和周围器官的相互作用。为了突出壁运动的影响，在健康人主动脉中与标准刚性壁模型进行比较。与规定室壁运动相关的额外计算成本较低（17%）。标准的血液动力学参数，如时间平均壁剪切应力和振荡剪切指数似乎在很大程度上不受壁运动，作为一个结果的平滑效应内在的时间平均。相反，瞬时壁面剪应力受壁面运动的影响很大;与刚性壁模型相比，壁面动力学似乎产生较低的壁面剪应力大小。此外，有人发现，如果考虑到壁运动的计算流场同意更好地与体内测量。这篇文章表明，它是可行的，包括测量特定主题的壁面运动的数值模拟，壁面运动很大程度上影响流场。这种方法，将测量运动应考虑在未来的研究动脉血流模拟。
AbstractPhysiologically relevant simulations of blood flow require models that allow for wall deformation. Normally a fluid–structure interaction (FSI) approach is used; however, this method relies on several assumptions and patient-specific material parameters that are difficult or impossible to measure in vivo. In order to circumvent the assumptions inherent in FSI models, aortic wall motion was measured with MRI and prescribed directly in a numerical solver. In this way is not only the displacement of the vessel accounted for, but also the interaction with the beating heart and surrounding organs. In order to highlight the effect of wall motion, comparisons with standard rigid wall models was performed in a healthy human aorta. The additional computational cost associated with prescribing the wall motion was low (17%). Standard hemodynamic parameters such as time-averaged wall shear stress and oscillatory shear index seemed largely unaffected by the wall motion, as a consequence of the smoothing effect inherent in time-averaging. Conversely, instantaneous wall shear stress was greatly affected by the wall motion; the wall dynamics seemed to produce a lower wall shear stress magnitude compared to a rigid wall model. In addition, it was found that if wall motion was taken into account the computed flow field agreed better with in vivo measurements. This article shows that it is feasible to include measured subject-specific wall motion into numerical simulations, and that the wall motion greatly affects the flow field. This approach to incorporate measured motion should be considered in future studies of arterial blood flow simulations.
影响因子：
5.3
作者：
Mynard, Jonathan P.;Wasserman, Bruce A.;Steinman, David A.
通讯作者：
Steinman, David A.
影响因子：
9.7
作者：
Taylor CA;Figueroa CA
通讯作者：
Figueroa CA