The role of the right superior temporal gyrus in stimulus-centered spatial processing.
The role of the right superior temporal gyrus in stimulus-centered spatial processing.
复制标题
DOI：
10.1016/j.neuropsychologia.2018.03.027
复制
发表时间：
2018-05
期刊：
影响因子：
2.6
通讯作者：
Hamilton RH
中科院分区：
文献类型：
--
作者：
Shah-Basak PP;Chen P;Caulfield K;Medina J;Hamilton RH
尽管新出现的神经心理学证据支持颞区，特别是右侧颞上回(STG)参与了向心性忽视缺陷，但STG在健康空间加工中的作用仍然难以捉摸。虽然一些脑功能成像研究已经证明STG参与了涉及以刺激为中心的外显判断的任务，但先前针对右侧STG的rTMS研究没有发现使用传统里程碑式任务的大小判断中预期的类似忽视的向右偏向。本研究的目的是研究用抑制性重复经颅磁刺激(RTMS)阻断右侧STG是否会影响健康人以刺激为中心的空间分配加工。这项具有里程碑意义的任务的侧化版本被开发出来，以强调以观众为中心的参照系和以刺激为中心的参照系之间的分离。我们预测，抑制右侧STG的活动会降低准确性，因为无论是以观众为中心还是以自我为中心的位置，以线刺激为中心的诱导右偏都会降低准确性。11名健康的右撇子成年人接受了这项具有里程碑意义的侧向任务。在观看完每个刺激后，参与者必须判断这条线是否被一分为二，或者这条线的左边(左边长的试验)或右边(右边长的试验)是否更长。受试者在接受rTMS前(rTMS前)和rTMS后(rTMS后)分别接受20分钟的1赫兹rTMS，对右侧STG、右侧边缘上回(SMG)和顶叶(一个对照部位)进行三次不同的检查。以准确度或判断误差作为因变量，建立了二项数据的线性混合模型，以比较1)试验类型(平分、非平分)的性能，以及2)顶点与STG以及顶点与SMG之间rTMS前后的性能。直线偏心率(z=4.31，p<；0.0001)和直线等分(z=5.49，p<；0.0001)是预测准确性的显著因素。在比较rTMS效果的模型中，与STG的显著双向交互作用(z=−3.09，p=0.002)显示，在左侧和右侧观众中心位置的对分试验中，准确率下降了9.5%，右长型错误增加了10.7%。左倾错误没有发现明显的变化。这些发现表明，在STG刺激后，受试者产生了以刺激为中心的右倾。值得注意的是，与顶点相比，SMG刺激并不影响准确性或误差。与我们的预测一致，这些发现为Right STG参与健康的以刺激为中心的空间加工提供了令人信服的证据。
Although emerging neuropsychological evidence supports the involvement of temporal areas, and in particular the right superior temporal gyrus (STG), in allocentric neglect deficits, the role of STG in healthy spatial processing remains elusive. While several functional brain imaging studies have demonstrated involvement of the STG in tasks involving explicit stimulus-centered judgments, prior rTMS studies targeting the right STG did not find the expected neglect-like rightward bias in size judgments using the conventional landmark task. The objective of the current study was to investigate whether disruption of the right STG using inhibitory repetitive transcranial magnetic stimulation (rTMS) could impact stimulus-centered, allocentric spatial processing in healthy individuals. A lateralized version of the landmark task was developed to accentuate the dissociation between viewer-centered and stimulus-centered reference frames. We predicted that inhibiting activity in the right STG would decrease accuracy because of induced rightward bias centered on the line stimulus irrespective of its viewer-centered or egocentric locations. Eleven healthy, right-handed adults underwent the lateralized landmark task. After viewing each stimulus, participants had to judge whether the line was bisected, or whether the left (left-long trials) or the right segment (right-long trials) of the line was longer. Participants repeated the task before (pre-rTMS) and after (post-rTMS) receiving 20 minutes of 1 Hz rTMS over the right STG, the right supramarginal gyrus (SMG), and the vertex (a control site) during three separate visits. Linear mixed models for binomial data were generated with either accuracy or judgment errors as dependent variables, to compare 1) performance across trial types (bisection, non-bisection), and 2) pre- vs. post-rTMS performance between the vertex and the STG and the vertex and the SMG. Line eccentricity (z = 4.31, p < .0001) and line bisection (z = 5.49, p < .0001) were significant predictors of accuracy. In the models comparing the effects of rTMS, a significant two-way interaction with STG (z = −3.09, p = .002) revealed a decrease in accuracy of 9.5% and an increase in errors of the right-long type by 10.7% on bisection trials, in both left and right viewer-centered locations. No significant changes in leftward errors were found. These findings suggested an induced stimulus-centered rightward bias in our participants after STG stimulation. Notably, accuracy or errors were not influenced by SMG stimulation compared to vertex. In line with our predictions, the findings provide compelling evidence for right STG’s involvement in healthy stimulus-centered spatial processing.
登录
查看更多内容
影响因子：
3.6
作者：
Khurshid, Shaan;Trupe, Lydia A.;Hillis, Argye E.
通讯作者：
Hillis, Argye E.
DOI：
10.3758/bf03199854
发表时间：
1979-01-01
期刊：
PERCEPTION & PSYCHOPHYSICS
影响因子：
--
作者：
JOHNSON, CA;LEIBOWITZ, HW
通讯作者：
LEIBOWITZ, HW
影响因子：
3.6
作者：
Baylis, GC;Baylis, LL;Gore, CL
通讯作者：
Gore, CL
影响因子：
2.6
作者：
McCourt, ME
通讯作者：
McCourt, ME
影响因子：
14.5
作者：
Ellison, A;Schindler, I;Milner, AD
通讯作者：
Milner, AD